Marileen Dogterom (Full Professor, BioNanoscience) studies cytoskeleton dynamics and synthetic cell construction. Research: (1) microtubule dynamics — force generation, catastrophe control, and mitotic spindle assembly reconstituted in vitro; (2) cell division reconstitution — building minimal synthetic cells with controlled division; (3) optical tweezers and fluorescence microscopy for force measurement on single cytoskeletal elements. Co-founded BioNanoscience department.
Dunsby co-invented oblique plane microscopy (a single-objective light-sheet technique) and develops multidimensional fluorescence lifetime and light-sheet imaging instrumentation for live-cell and tissue imaging, applied to cancer diagnostics and cell biology.
Edel's group develops nanopore- and nanogap-based single-molecule sensing platforms, combining nanofluidics, plasmonics and electrical/optical readout for ultrasensitive detection and sequencing of biomolecules.
Fleming pioneered microstructured polymer optical fibre and continues to work on specialty fibre fabrication: drawing exotic polymer, hybrid polymer-metal and poled-silicate structures that would be impossible in conventional silica, and using them to build metamaterials and biomedical photonic devices including fibre-based sensors and probes. The fabrication route — preform drawing — gives access to geometries and material combinations that lithography cannot reach. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the relevance to a sensing postdoc is delivery and packaging: fibre-integrated probes are the standard way to get an NV or vapour-cell sensor into a biological or field environment while preserving its pT/sqrt(Hz) sensitivity. Borderline inclusion; senior PI, fabrication-led.
Fletcher combines optical and force microscopy (AFM, optical tweezers) with purified-protein and single-cell assays to measure the mechanics of cell movement and immune-cell activation, and has also developed low-cost imaging instrumentation (foldscopes, phone-based microscopes) for global health.
Gambin was the first EMBL Australia group leader appointed to Single Molecule Science. His signature method combines cell-free protein expression with two-colour single-molecule coincidence and fluctuation spectroscopy, which sidesteps purification entirely: proteins are expressed, labelled and measured in lysate, an order of magnitude faster than conventional interaction assays. The biology is protein self-association and aggregation — alpha-synuclein in Parkinson's, cardiac and muscular disease proteins — where the size distribution of oligomers, not the mean, is the quantity of interest. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the conceptual overlap with quantum biosensing is the insistence on distributions over averages, and his aggregation systems (paramagnetic-species-generating, redox-active amyloid) are a plausible target for T1-relaxometry-based NV detection at pT/sqrt(Hz) in the near term.
Gardner's group develops infrared and Raman microspectroscopy for biomedical diagnostics and disease sensing. Research directions: (1) FTIR synchrotron microspectroscopy — using Diamond Light Source synchrotron IR beam for high-spatial-resolution chemical mapping of biological tissues for cancer diagnosis; (2) Raman microspectroscopy — label-free chemical imaging of cells and tissue for disease classification using machine-learning chemometrics; (3) SERS probes — developing gold nanoparticle SERS labels for targeted cancer biomarker detection; (4) Breathomics — on-chip photonic sensors for exhaled breath analysis for early disease detection. The infrared and Raman methods provide label-free molecular sensing with potential for quantum-enhanced sensitivity.
Garner uses high-resolution, single-molecule tracking and localization microscopy (PALM-based) to study the dynamic spatial organization of the bacterial cytoskeleton and cell-wall synthesis machinery in live prokaryotic cells at nanometer precision.
Garrido is a computational cognitive neuroscientist — predictive coding, Bayesian brain models, neuroimaging biomarkers for mental health — who was appointed a chief investigator of the ARC Centre of Excellence in Quantum Biotechnology specifically to work with the Melbourne and UQ physics groups on non-invasive quantum-sensor recording of human brain magnetic fields. She is the human-subject and source-reconstruction end of the QUBIC portable-brain-imager programme: her lab supplies the paradigms, the clinical cohorts and the inverse-problem modelling that a diamond- or OPM-based MEG system has to serve. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — she is not a sensor developer, but she is the reason the pT/sqrt(Hz)-class magnetometers being built at Melbourne have a human-trials pathway at all. Preferred attributes present in strength: bioelectromagnetism and human trials with novel quantum technologies. Included as a deliberate borderline case — a sensing postdoc would be the physics half of a collaboration with this lab, not a member of it.
Hylkje Geertsema uses single-molecule super-resolution fluorescence microscopy (TIRF, SMLM, PALM/STORM) to study DNA replication dynamics. Her lab visualises and quantifies individual replication proteins at replication forks in living cells to understand the kinetics and fidelity of DNA copying. Research focuses on measuring spatiotemporal dynamics of protein assemblies during DNA metabolism with nanometre resolution.