Research Areas - (4) Genetically-Encoded Voltage Indicator Imaging

Full path: Biology > Biophysics > Quantum Biology / Biosensing > Voltage Imaging / Optogenetics Biosensing > Genetically-Encoded Voltage Indicator Imaging

Department(s)/lab(s): Imaging Physics (ImPhys) | Brinks Lab @ TU Delft
Summary:

Daan Brinks develops all-optical electrophysiology tools for neuroscience. His lab engineers genetically-encoded voltage indicators (GEVIs) and combines them with optogenetics to read out and control neural circuit activity. Key directions: (1) engineering bright, fast GEVIs with improved photostability and voltage sensitivity; (2) multiplexed all-optical neural circuit mapping; (3) identifying rare aggressive cancer cells using voltage-sensitive dyes. His voltage imaging approach represents cutting-edge biosensing at the intersection of photonics and neuroscience.

Department(s)/lab(s): Chemistry and Chemical Biology, Physics | Cohen Lab @ Harvard
Summary:

Cohen's lab develops genetically encoded fluorescent voltage indicators and all-optical electrophysiology ('Optopatch') to simultaneously stimulate and image membrane voltage in individual neurons and cardiomyocytes at the single-cell and network level, combining protein engineering, optics, and theory to push the temporal and spatial resolution of bioelectrical imaging well past conventional patch-clamp limits.

Department(s)/lab(s): Melbourne School of Psychological Sciences | Garrido Cognitive Neuroscience and Computational Psychiatry Laboratory @ UMelb
Summary:

Garrido is a computational cognitive neuroscientist — predictive coding, Bayesian brain models, neuroimaging biomarkers for mental health — who was appointed a chief investigator of the ARC Centre of Excellence in Quantum Biotechnology specifically to work with the Melbourne and UQ physics groups on non-invasive quantum-sensor recording of human brain magnetic fields. She is the human-subject and source-reconstruction end of the QUBIC portable-brain-imager programme: her lab supplies the paradigms, the clinical cohorts and the inverse-problem modelling that a diamond- or OPM-based MEG system has to serve. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — she is not a sensor developer, but she is the reason the pT/sqrt(Hz)-class magnetometers being built at Melbourne have a human-trials pathway at all. Preferred attributes present in strength: bioelectromagnetism and human trials with novel quantum technologies. Included as a deliberate borderline case — a sensing postdoc would be the physics half of a collaboration with this lab, not a member of it.

Department(s)/lab(s): Genetics | Ting Lab @ Stanford
Summary:

Ting's lab invented proximity-dependent enzymatic labeling technologies (APEX, TurboID) that map the spatial proteome and transcriptome of living cells with organelle-level resolution, and develops genetically encoded fluorescent/voltage biosensors -- engineering biology's own molecular machinery into quantitative optical reporters.