Tags - (4) QUBIC quantum biotechnology

Department(s)/lab(s): Melbourne School of Psychological Sciences | Garrido Cognitive Neuroscience and Computational Psychiatry Laboratory @ UMelb
Summary:

Garrido is a computational cognitive neuroscientist — predictive coding, Bayesian brain models, neuroimaging biomarkers for mental health — who was appointed a chief investigator of the ARC Centre of Excellence in Quantum Biotechnology specifically to work with the Melbourne and UQ physics groups on non-invasive quantum-sensor recording of human brain magnetic fields. She is the human-subject and source-reconstruction end of the QUBIC portable-brain-imager programme: her lab supplies the paradigms, the clinical cohorts and the inverse-problem modelling that a diamond- or OPM-based MEG system has to serve. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — she is not a sensor developer, but she is the reason the pT/sqrt(Hz)-class magnetometers being built at Melbourne have a human-trials pathway at all. Preferred attributes present in strength: bioelectromagnetism and human trials with novel quantum technologies. Included as a deliberate borderline case — a sensing postdoc would be the physics half of a collaboration with this lab, not a member of it.

Department(s)/lab(s): School of Physics (joint with Biochemistry and Pharmacology) | Hinde Laboratory (Cell Nucleus Biophysics) @ UMelb
Summary:

Hinde is a fluorescence-fluctuation physicist embedded in cell biology: she uses pair-correlation function analysis, number-and-brightness, phasor-FLIM and FRET to read out chromatin compaction, protein-chromatin binding dynamics and nucleocytoplasmic transport in living nuclei, at spatial and temporal scales that conventional imaging averages away. The programme is a technique-pushing one — the emphasis is on extracting nanoscale structural information from photon statistics rather than on brute-force localisation — and it is now being coupled to quantum sensing through her QUBIC investigatorship, where the goal is to combine fluorescence readouts with NV-based magnetic and spin-noise contrast in the same cell. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — her role in QUBIC is to supply the cell-biological questions and the correlative optical readouts that make pT/sqrt(Hz)-class ensemble sensing biologically interpretable. Preferred attribute present: lifetime- and orientation-resolved methods pushing past the usual resolution limits.

Department(s)/lab(s): School of Physics | Quantum Biotechnology and Diamond Sensing Group (Hollenberg) @ UMelb
Summary:

Hollenberg is the intellectual centre of gravity for diamond quantum sensing in Australia: a theorist-turned-programme-leader whose group develops NV-based quantum probes for biological systems and quantum-computing architectures in silicon and diamond. Current directions include the quantum-probe hyperspectral microscope, in which NV ensembles in a bulk diamond substrate report magnetic and spin-noise contrast from cells cultured directly on the surface; nanodiamond quantum probes for intracellular relaxometry and free-radical detection; theory of decoherence-based sensing (T1 relaxometry as a chemical-specificity channel rather than a nuisance); and single-cell magnetic resonance. He co-leads the Melbourne node of the ARC Centre of Excellence in Quantum Biotechnology (QUBIC) with Simpson and Hinde, which is explicitly chartered to build quantum sensors for live biology, including portable brain imagers. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — his programme is one of the small number worldwide that has carried those ensemble protocols all the way into cell culture and tissue rather than stopping at proof-of-principle magnetometry. Preferred attribute present: the group's emphasis is on sensitivity and biological specificity rather than device fabrication, and QUBIC funding runs to 2030 with recurring postdoc recruitment.

Department(s)/lab(s): School of Physics | Quantum Imaging and Sensing Laboratory (Simpson) @ UMelb
Summary:

Simpson runs the experimental quantum imaging and sensing laboratory at Melbourne and is the closest match at this institution to a bio-oriented NV sensing postdoc. Two active threads: (i) widefield NV magnetic and spin-relaxation imaging of living cells and tissue, including magnetic imaging of magnetotactic bacteria, cellular free radicals and paramagnetic ion transport, and quantum-probe imaging of neuronal activity; and (ii) engineering Australia's most sensitive diamond vector magnetometer with RMIT and Phasor Innovation, aimed at navigation, underground/undersea sensing and, explicitly, mapping magnetic signals of the human brain in unshielded environments. That second thread is a direct bid at bioelectromagnetism with a quantum sensor. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — Simpson's work is a continuation of exactly that lineage, pushing ensemble DEER/T1-relaxometry contrast mechanisms out of the physics lab and into cell biology and human-scale magnetoencephalography. Preferred attributes present: bioelectromagnetism, human-subject ambitions, sensitivity-limited (not fabrication-limited) programme. QUBIC investigator; recruits postdocs regularly.