Barbosa de Aguiar develops label-free, chemically-selective coherent Raman (CARS/SRS) and computational microscopy — including compressive-sensing-accelerated Raman microspectroscopy and wavefront-shaping through strongly scattering biological tissue — to push spatial and spectral resolution of label-free biomedical imaging, working within Sylvain Gigan's Complex Media Optics team (Photonics, Information & Complexity axis).
Bohndiek's VISION Lab, run jointly between the Cavendish Laboratory and the Cancer Research UK Cambridge Institute, develops low-cost optical and photoacoustic imaging technologies to study the tumour microenvironment and vasculature, with a strong translational focus on early cancer detection (e.g. hyperspectral endoscopy for oesophageal cancer). The lab is part of a large interdisciplinary team and regularly recruits postdoctoral researchers.
Brasselet is a CNRS researcher at Institut Fresnel developing polarization- and orientation-resolved fluorescence microscopy, using controlled excitation and detection polarization states to map the 3D orientation and organization of fluorescent probes and biomolecular assemblies (e.g. lipid order, amyloid and cytoskeletal structures) at and beyond the single-molecule level, including recent work on the mathematical foundations of polarimetric microscopy.
Dunsby co-invented oblique plane microscopy (a single-objective light-sheet technique) and develops multidimensional fluorescence lifetime and light-sheet imaging instrumentation for live-cell and tissue imaging, applied to cancer diagnostics and cell biology.
Fleming pioneered microstructured polymer optical fibre and continues to work on specialty fibre fabrication: drawing exotic polymer, hybrid polymer-metal and poled-silicate structures that would be impossible in conventional silica, and using them to build metamaterials and biomedical photonic devices including fibre-based sensors and probes. The fabrication route — preform drawing — gives access to geometries and material combinations that lithography cannot reach. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the relevance to a sensing postdoc is delivery and packaging: fibre-integrated probes are the standard way to get an NV or vapour-cell sensor into a biological or field environment while preserving its pT/sqrt(Hz) sensitivity. Borderline inclusion; senior PI, fabrication-led.
Goldys was Deputy Director of the ARC Centre of Excellence for Nanoscale BioPhotonics and now leads a nanoscale biophotonics group in Biomedical Engineering. The programme is about extracting diagnostic information from very weak optical signals inside cells and tissue: luminescent and upconverting nanoparticle probes with long lifetimes that allow time-gated, background-free detection; hyperspectral unmixing of native cellular autofluorescence (NADH, FAD, porphyrins) as a completely label-free readout of cell state, which she has pushed toward clinical use in reproductive medicine and cancer; and nanoparticle-mediated therapy. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — time-gated luminescence and NV relaxometry are two solutions to the same problem — how to read a faint, specific signal out of an autofluorescent, optically hostile biological background — and her clinical translation experience is exactly the missing capability in most quantum-biosensing groups. Preferred attribute present: advanced/label-based imaging with a genuine human-application pathway.
Gureyev is one of the originators of propagation-based X-ray phase-contrast imaging and the transport-of-intensity phase-retrieval methods that made it practical; his current work concerns the information-theoretic limits of imaging — how signal-to-noise, spatial resolution and radiation dose trade against one another — and the application of those limits to phase-contrast tomography, ptychography and electron microscopy, including biomedical imaging at clinically tolerable dose. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the shared intellectual core is the noise-resolution-dose triangle: the same estimation-theory framework that sets the pT/sqrt(Hz) floor of an NV ensemble governs how many photons a phase-contrast image needs. Borderline inclusion (X-ray rather than quantum sensing), kept because the technique is explicitly about pushing resolution past conventional limits.
Hinde is a fluorescence-fluctuation physicist embedded in cell biology: she uses pair-correlation function analysis, number-and-brightness, phasor-FLIM and FRET to read out chromatin compaction, protein-chromatin binding dynamics and nucleocytoplasmic transport in living nuclei, at spatial and temporal scales that conventional imaging averages away. The programme is a technique-pushing one — the emphasis is on extracting nanoscale structural information from photon statistics rather than on brute-force localisation — and it is now being coupled to quantum sensing through her QUBIC investigatorship, where the goal is to combine fluorescence readouts with NV-based magnetic and spin-noise contrast in the same cell. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — her role in QUBIC is to supply the cell-biological questions and the correlative optical readouts that make pT/sqrt(Hz)-class ensemble sensing biologically interpretable. Preferred attribute present: lifetime- and orientation-resolved methods pushing past the usual resolution limits.
Kaminski's Laser Analytics Group develops laser-based super-resolution and fluorescence-lifetime imaging methods (STED, SIM, dSTORM, FLIM) and applies them, with long-time collaborator Gabriele Kaminski Schierle, to visualise amyloid protein aggregation in live cells and organisms as a route to understanding neurodegenerative disease; the group also directs the EPSRC Centre for Doctoral Training in Sensor Technologies.
Kaminski Schierle heads the Molecular Neuroscience Group, applying super-resolution and functional fluorescence imaging (developed with Clemens Kaminski) to gain molecular-level understanding of protein misfolding in Alzheimer's, Parkinson's and Huntington's disease models, including live-cell and whole-organism (C. elegans) imaging of amyloid aggregation.