Description: Fourier-domain OCT and spectroscopic OCT for tissue structural and functional imaging.
Bohndiek's VISION Lab, run jointly between the Cavendish Laboratory and the Cancer Research UK Cambridge Institute, develops low-cost optical and photoacoustic imaging technologies to study the tumour microenvironment and vasculature, with a strong translational focus on early cancer detection (e.g. hyperspectral endoscopy for oesophageal cancer). The lab is part of a large interdisciplinary team and regularly recruits postdoctoral researchers.
Develops novel optical biomedical imaging technologies (OCT, nonlinear/multiphoton microscopy) for cancer detection, primary-care diagnostics, and neurophotonics, and translates them toward clinical and commercial application.
Jeroen Kalkman develops optical tomography and spectroscopy methods for biomedical imaging. Research: (1) Fourier-domain OCT including spectroscopic OCT for tissue structural and functional imaging; (2) novel light sources and detectors for skin cancer detection (NWO KIC project NextDeLights); (3) scattering media imaging. His work is relevant to advanced biosensing with optical coherence.
Zhang's lab develops two core optical technologies: spectroscopic single-molecule localization microscopy (sSMLM), which multiplexes emission-spectrum measurement with single-molecule localization to reach ~5 nm spatial resolution, and visible-light optical coherence tomography (vis-OCT), which exploits higher tissue contrast at visible wavelengths for micron-scale retinal and tumor-vasculature imaging in patients. Applications span cancer nanopathology and ophthalmology, including in-vivo human retinal oximetry.