Backman develops nanoscale-sensitive optical biophotonics -- including chromatin-sensitive partial-wave spectroscopic (PWS) microscopy, which is label-free and detects mass-density fluctuations of chromatin packing domains below the diffraction limit -- and combines it with super-resolution imaging, electron tomography, and computational genome modeling in his nano-ChIA platform. The lab links this multi-scale nanoscale chromatin imaging to gene-expression physics and has translated the technology into cancer early-detection diagnostics through several spinout companies.

Prof. Figueroa-Feliciano leads Northwestern's experimental program in quantum sensing for particle physics. Key directions: (1) SuperCDMS SNOLAB — Northwestern's NU's role in the Super Cryogenic Dark Matter Search at SNOLAB (2 km underground in Canada), using ultra-pure Si and Ge crystals with superconducting TES sensors to detect low-mass dark matter (particles below the proton mass); in March 2026 the experiment reached operating temperature (<10 mK), transitioning to detector calibration for the first ever dark matter search at the site; (2) NEXUS facility at Fermilab: Northwestern-built test facility led by Figueroa-Feliciano for SuperCDMS detector calibration and for measuring how ionizing radiation affects superconducting qubits (published fall 2025); (3) Qubit-based quantum sensing: developing HVeV R&D devices with <1 eV resolution and qubit parity-detection techniques for eV-scale and sub-eV dark matter detection. Associate Vice President for Research at Northwestern; INQUIRE Executive Committee. Joint appointment at Fermilab.

Gabrielse directs Northwestern's Center for Fundamental Physics at Low Energy, where his group performs some of the most precise measurements of any single particle. Using a one-electron quantum cyclotron in a cylindrical Penning trap, his team measures the electron magnetic moment (g-factor) to sub-part-per-trillion precision, providing the most stringent test of quantum electrodynamics and the Standard Model. A parallel effort (ACME) searches for the electron's electric dipole moment using a cold beam of ThO molecules, and a new cavity-based dark-matter search and antihydrogen/antiproton precision-measurement program are underway. This is precision quantum sensing of fundamental constants rather than sensing of an external field, but it shares with NV-ensemble magnetometry the goal of pushing measurement sensitivity toward the quantum limit through improved back-action evasion.

Prof. Gaynor (Chemistry, joined summer 2023) develops cutting-edge ultrafast spectroscopy at the physics-chemistry frontier. Directions: (1) Attochemistry — new ultrafast laser spectroscopies operating on attosecond to femtosecond timescales to directly measure how electron spin and orbital motion couple to molecular geometry (spin-vibronic coupling) in chiral molecules and materials of interest for energy conversion and spintronics; (2) Multidimensional nonlinear spectroscopy (2D electronic spectroscopy, 2D vibrational) to track energy and charge transfer immediately after photoexcitation; (3) Instrumentation-first approach: building novel attosecond transient absorption and correlation spectroscopy apparatus from scratch, enabling entirely new observables (e.g., electron-nuclear and spin-orbital correlations). INQUIRE faculty affiliate. Beckman Young Investigator 2025 ($600k, 4 yrs); Packard Fellow 2025 ($875k, 5 yrs).

The Geraci group employs high-Q resonant sensors for ultra-sensitive force and field detection in searches for new physics beyond the Standard Model. Key thrusts: (1) Optically-trapped levitated dielectric nanospheres and microspheres achieving zeptonewton (10⁻²¹ N) force sensitivity, applied to probing short-range deviations from Newtonian gravity at micrometer scales; (2) ARIADNE, an international NMR-based experiment using superfluid ³He to search for the QCD axion via axion-mediated spin-dependent forces between a rotating mass and polarized nuclei; (3) Collaboration on MAGIS-100, the 100 m-tall atom interferometer at Fermilab for gravitational wave detection in the mid-band (0.3–10 Hz) and ultralight dark matter searches; (4) Cryogenic optical cavity dark matter comparisons with Gabrielse and Kovachy groups. Member of CFP Northwestern and CIERA. APS Francis M. Pipkin Award 2023.

Grassellino directs the DOE's SQMS Center, a Fermilab-Northwestern-led national quantum initiative center, and pioneered nitrogen-doping surface treatments that give niobium superconducting RF (SRF) cavities record-high quality factors. Beyond their traditional use in particle accelerators, these ultra-high-Q cavities are now deployed as extremely sensitive electromagnetic detectors: the Dark SRF experiment set new sensitivity limits on dark-photon light-shining-through-wall searches, and SRF cavities (e.g. the MAGO design) are being explored as high-frequency gravitational-wave and axion detectors, alongside long-lived multimode quantum memories for superconducting quantum computing.

The Han Lab (Chemistry, joined fall 2023) develops quantum sensing tools rooted in electron and nuclear spin physics for life-science applications. Directions: (1) DNP-enhanced NMR quantum sensing using coupled electron-nuclear spin clusters — designing novel biradical and multi-spin systems achieving 700-fold ¹³C signal enhancement at 14.1 T via P1 center clusters in HPHT diamond (exchange coupling >100 MHz); aiming for in-cell NMR with sensitivity to track water dynamics in a single cell; (2) High-field pulsed EPR at 240 GHz / 8.6 T: time-resolved Gd-Gd EPR (TiGGER) for tracking inter-residue distances during protein functional cycles in solution with sub-nm resolution; rapid-scan field-domain EPR development; (3) Integration of DNP/EPR with nanodiamond-based quantum sensors: coupled electron-nuclear spin cluster design for long-range quantum sensing in biological environments, bridging conventional NMR/EPR and NV-center-based quantum sensing. Han directs the EPR/DNP component of IMSERC (Northwestern's core facility) and brought three new EPR spectrometers and a 600 MHz DNP-NMR system.

Hoffman develops and applies electron-nuclear double resonance (ENDOR) spectroscopy -- a combination of EPR and NMR -- to resolve individual hyperfine-coupled nuclei at metalloenzyme active sites with atomic-scale precision, work that has revealed mechanisms of nitrogenase nitrogen fixation, radical-SAM enzyme catalysis, and copper/methane monooxygenase chemistry. The technique pushes magnetic-resonance spectroscopic resolution well past what conventional EPR can resolve, in a manner methodologically continuous with molecular spin-qubit sensing.

The Hosseini Lab (Quantum Atom Optics) investigates light–atom interactions in rare-earth crystals, room-temperature gases, and nanophotonic structures. Directions: (1) Quantum optical memories in Tm³⁺:YAG and Er³⁺-doped solids using atomic frequency comb (AFC) and gradient echo memory (GEM) protocols for telecom-wavelength quantum networking; demonstrated efficient storage of multi-dimensional telecom photons (Optica Quantum 2025, Phys. Rev. Appl. 2025); (2) Cooperative/collective light–matter interactions in periodic rare-earth ion arrays in nano/micro-photonic structures (collaboration with Oak Ridge NL, Aydin group) for enhanced quantum memory coherence; (3) Quantum squeezed light — applied to enhanced thermoreflectance sensing of electronic hotspots (Appl. Phys. Lett. 2024); (4) Coherent levitation of macroscopic sensors (DARPA YFA 2024, $500k): magnetic and optical trapping of mm-scale objects as high-Q oscillators for magnetometry, vibrational sensing, accelerometry, inertial, and force sensing. Lab actively seeking postdocs in integrated photonics, quantum memory, and levitation sensing (2024–2025). ASEE Curtis W. McGraw Research Award 2026.

Prof. Jacobsen's group develops novel methods, instruments, and analysis approaches for X-ray nanoscale imaging and applies them to biology and environmental science, using the Advanced Photon Source (APS) at Argonne. Directions: (1) Scanning X-ray fluorescence microscopy (SXFM) for organ-wide and nanoscale elemental mapping of metals (zinc, copper, iron) in biological tissues — central to the NIH-funded QE-Map national resource; imaging how metals regulate cellular functions, synaptic zinc signaling, and neurodegenerative disease; (2) X-ray ptychography and coherent diffractive imaging (CDI) for nanoscale biological imaging beyond the diffraction limit with improved dose efficiency; (3) Development of new algorithms, optics (zone plates), and detector systems to push spatial resolution and dose efficiency in X-ray microscopy — including lensless imaging methods and compressed-sensing reconstruction. Joint appointment at Argonne National Laboratory (Argonne Distinguished Fellow); also involved in QE-Map resource with Kozorovitskiy and Hao Zhang (McCormick).