Description: Microwave-driven transfer of electron spin polarization to nuclei to boost NMR signal by orders of magnitude.
Ajoy's group uses NV and P1 centers in diamond to hyperpolarize nuclear spins via optically pumped dynamic nuclear polarization, dramatically boosting NMR/MRI signal for chemical sensing and nanoscale spectroscopy. This builds directly on the broader lineage of NV-ensemble quantum sensing experiments (DEER, nanoscale NMR, T1 relaxometry) that have reached pT/sqrt(Hz)-class sensitivities, extending it toward practical hyperpolarized-sensing applications; the lab is actively recruiting postdocs.
Gruetter leads the Laboratory for Functional and Metabolic Imaging (LFMI) at EPFL and co-directs the CIBM (Centre for Biomedical Imaging). Research directions: (1) Ultra-high-field in vivo MR spectroscopy โ developing 1H, 13C, 31P, 23Na MRS at 14.1T animal and 7T human systems to measure metabolite concentrations (glutamate, GABA, lactate) in brain with unprecedented sensitivity; (2) Quantum coherence effects in NMR โ exploiting J-coupling evolution and JPRESS sequences for quantum-selective metabolite editing; (3) Hyperpolarization โ DNP-enhanced metabolite sensing in vivo for tracking metabolic flux in real time; (4) Neuroimaging โ quantitative BOLD fMRI calibration and cerebral blood flow mapping. The 14.1T magnet is among the world's most powerful for biological NMR spectroscopy.
The Han Lab (Chemistry, joined fall 2023) develops quantum sensing tools rooted in electron and nuclear spin physics for life-science applications. Directions: (1) DNP-enhanced NMR quantum sensing using coupled electron-nuclear spin clusters โ designing novel biradical and multi-spin systems achieving 700-fold ยนยณC signal enhancement at 14.1 T via P1 center clusters in HPHT diamond (exchange coupling >100 MHz); aiming for in-cell NMR with sensitivity to track water dynamics in a single cell; (2) High-field pulsed EPR at 240 GHz / 8.6 T: time-resolved Gd-Gd EPR (TiGGER) for tracking inter-residue distances during protein functional cycles in solution with sub-nm resolution; rapid-scan field-domain EPR development; (3) Integration of DNP/EPR with nanodiamond-based quantum sensors: coupled electron-nuclear spin cluster design for long-range quantum sensing in biological environments, bridging conventional NMR/EPR and NV-center-based quantum sensing. Han directs the EPR/DNP component of IMSERC (Northwestern's core facility) and brought three new EPR spectrometers and a 600 MHz DNP-NMR system.
McCamey is, for a candidate coming from NV ensemble sensing, the single most methodologically adjacent PI at UNSW. His laboratory does optically and electrically detected magnetic resonance on spins that are not defects in diamond: photogenerated spin-correlated radical pairs, triplet excitons in organic semiconductors, singlet-fission intermediates, and molecular spin systems. The instrumentation is the same toolkit โ pulsed EPR, ODMR, dynamical decoupling, relaxometry โ applied to systems where the spin is created by light and reports on chemistry. He directs the UNSW node of ARC Exciton Science. Positioned against the established body of NV-ensemble quantum sensing work โ DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity โ his group runs precisely those pulse sequences (Hahn echo, DEER, relaxometry) on a different spin species, and radical-pair spin chemistry is one of the few plausible mechanisms by which biology could be genuinely quantum โ which makes this a strong landing spot for someone wanting to keep the NV skill set but change the physical system. Preferred attributes present: sensitivity-limited spin measurement, quantum-biology relevance.
Reilly's Quantum Nanoscience Laboratory works on the interface between quantum devices and the classical control hardware needed to run them at scale โ custom VLSI CMOS operating below 100 mK, high-bandwidth dispersive readout, and cryogenic microwave engineering โ a programme built up during his long association with Microsoft's quantum effort. A distinct and directly relevant second thread is the manipulation of spin states in nanoparticles for new imaging modalities in medicine: hyperpolarisation and spin-state engineering of nanoparticle contrast agents, which is quantum control applied to MRI. Positioned against the established body of NV-ensemble quantum sensing work โ DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity โ the cryo-CMOS readout chain he builds is exactly the enabling technology that would let a pT/sqrt(Hz) spin-ensemble sensor be multiplexed into an array rather than run one channel at a time; and the nanoparticle-MRI thread is an independent route into biological spin sensing. Large group, strong engineering culture, significant industry entanglement.