Research Areas - (5) Infrared / Raman Microspectroscopy for Biomedical Sensing

Full path: Biology > Biophysics > Quantum Biology / Biosensing > Infrared / Raman Microspectroscopy for Biomedical Sensing

Darren Graham 🔗
University of Manchester 🔗
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Department(s)/lab(s): Physics & Astronomy – Photon Science Institute | Graham Group (SERS and Nanoplasmonic Biosensing) @ Manchester
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Graham's group develops SERS-based nanoplasmonic sensing platforms for biomedical applications. Research directions: (1) SERS nanogap substrates — engineering colloidal gold and silver nanostructure clusters with reproducible, high-enhancement nanogaps for single-molecule SERS detection; (2) In vivo SERS — intravenous SERS nanotags for tumor imaging and multiplexed biomarker detection in living organisms; (3) Microfluidic SERS — integrating SERS probes in microfluidic channels for continuous monitoring of circulating biomarkers; (4) Quantitative SERS — calibration strategies for absolute analyte quantification for clinical diagnostics. Extreme sensitivity (single-molecule) relevant to quantum-enhanced optical sensing.

Jeroen Kalkman 🔗
Delft University of Technology 🔗
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Department(s)/lab(s): Imaging Physics (ImPhys) | Kalkman Lab (OCT Spectroscopy) @ TU Delft
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Jeroen Kalkman develops optical tomography and spectroscopy methods for biomedical imaging. Research: (1) Fourier-domain OCT including spectroscopic OCT for tissue structural and functional imaging; (2) novel light sources and detectors for skin cancer detection (NWO KIC project NextDeLights); (3) scattering media imaging. His work is relevant to advanced biosensing with optical coherence.

Robbie Murray 🔗
Imperial College London 🔗
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Department(s)/lab(s): Physics | Mid-Infrared Photonics Group @ Imperial
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Murray develops mid-infrared photonic sources and detectors and combines mid-IR spectroscopy with mass-spectrometry imaging to provide complementary optical and biochemical maps of tissue for biomedical sensing.

Chris Phillips 🔗
Imperial College London 🔗
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Department(s)/lab(s): Physics | Quantum Imaging Group (Digistain) @ Imperial
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Phillips works on quantum imaging (entangled/twin-photon imaging at the quantum limit) and label-free mid-infrared spectroscopic biomedical imaging; he co-founded Digistain, a spin-out applying infrared spectroscopic histopathology to rapid cancer diagnostics.

Vladislav Yakovlev 🔗
Texas A&M University 🔗
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Department(s)/lab(s): Biomedical Engineering | Advanced Spectroscopy Lab @ TAMU
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Yakovlev develops label-free biomedical imaging: Brillouin micro-spectroscopy of cell/tissue viscoelasticity, impulsive stimulated Brillouin scattering, SERS and coherent-Raman diagnostics, and quantum-enhanced (photon-number-resolving, sub-shot-noise) optical imaging in collaboration with Agarwal/Scully. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work provides the biomedical, quantum-enhanced-imaging bridge for spin-sensor bio-applications.