Technique - (6) Coherent Raman scattering microscopy (CARS/SRS)

Type: Experimental

Description: Label-free vibrational imaging of biological samples using coherent anti-Stokes or stimulated Raman scattering.

Department(s)/lab(s): Physics (LKB) | Complex Media Optics Team (PICO) @ ENS Paris
Summary:

Barbosa de Aguiar develops label-free, chemically-selective coherent Raman (CARS/SRS) and computational microscopy β€” including compressive-sensing-accelerated Raman microspectroscopy and wavefront-shaping through strongly scattering biological tissue β€” to push spatial and spectral resolution of label-free biomedical imaging, working within Sylvain Gigan's Complex Media Optics team (Photonics, Information & Complexity axis).

Department(s)/lab(s): Engineering | Institut Fresnel - MOSAIC Biophotonics Team @ CNRS
Summary:

Rigneault leads the MOSAIC team at Institut Fresnel, developing label-free nonlinear optical microscopy (CARS/SRS) for chemically-specific imaging of lipids and biomolecules in tissue, and pioneering lensless, hair-thin fiber-bundle endoscopes based on wavefront control for minimally invasive deep-tissue and in vivo biological imaging. He holds 17 patents in optical engineering and molecular spectroscopy for the life sciences.

Department(s)/lab(s): Bioengineering | Rowlands Optical Technologies Group @ Imperial
Summary:

Rowlands develops new optical imaging technologies for biology and medicine, including label-free vibrational (coherent Raman) microscopy and computational imaging approaches aimed at faster, higher-resolution biomedical imaging.

Department(s)/lab(s): Physics & Astronomy | Scully Group / Institute for Quantum Science and Engineering @ TAMU
Summary:

Scully directs IQSE and pursues foundational quantum optics: quantum coherence effects (lasing without inversion, electromagnetically induced transparency), collective/superradiant emission, quantum-enhanced spectroscopy, and coherent-Raman schemes (FAST CARS) for real-time detection of pathogens and molecular fingerprints. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work sits on the fundamental-light side, providing coherence and superradiance concepts that inform quantum-enhanced magnetometry read-out.

Department(s)/lab(s): Physics & Astronomy | Sokolov Laboratory (IQSE) @ TAMU
Summary:

Sokolov develops femtosecond adaptive spectroscopic techniques for coherent Raman (FAST CARS), broadband stochastic laser fields, and quantum-light probes of molecular coherence for standoff chemical/biological sensing and label-free imaging. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work contributes ultrafast coherent-Raman methodology adjacent to spin-based sensing.

Department(s)/lab(s): Biomedical Engineering | Advanced Spectroscopy Lab @ TAMU
Summary:

Yakovlev develops label-free biomedical imaging: Brillouin micro-spectroscopy of cell/tissue viscoelasticity, impulsive stimulated Brillouin scattering, SERS and coherent-Raman diagnostics, and quantum-enhanced (photon-number-resolving, sub-shot-noise) optical imaging in collaboration with Agarwal/Scully. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work provides the biomedical, quantum-enhanced-imaging bridge for spin-sensor bio-applications.