Dunsby co-invented oblique plane microscopy (a single-objective light-sheet technique) and develops multidimensional fluorescence lifetime and light-sheet imaging instrumentation for live-cell and tissue imaging, applied to cancer diagnostics and cell biology.
Klenerman develops and applies single-molecule fluorescence and scanning-probe methods (including nanopipette scanning ion-conductance microscopy and a single-objective oblique-plane light-sheet microscope) to study protein misfolding and aggregation in neurodegenerative disease, alongside his earlier work co-inventing next-generation DNA sequencing.
Prof. Kozorovitskiy (Neurobiology) studies neuromodulation and plasticity in the striatum and basal ganglia, with a distinctive emphasis on developing and applying advanced optical imaging methods. Imaging technique innovations: (1) Oblique plane illumination (OPI / scanned oblique plane illumination, SOPi) microscopy — a single-objective light-sheet technique achieving tilt-invariant volumetric imaging for rapid 3D capture of fluorescently labeled neural structures without mechanical tilting; (2) Two-photon fluorescence imaging and two-photon glutamate/neuromodulator photorelease for single-synapse resolution in live tissue; (3) Near-infrared genetically-encoded calcium indicators (with Verkhusha group) for in vivo multi-color neural recording with reduced photobleaching. The lab's technical contributions are centered on extending the spatial and volumetric resolution of live-tissue fluorescence imaging. Irving M. Klotz Research Professor of Neurobiology; Beckman Young Investigator 2015.
Jörg Müller's Quantum Metrology group works on next-generation optical atomic clocks and superradiant lasers. Key experiments: cold strontium continuous superradiant laser (subnatural linewidth, pushing beyond traditional clock limitations); microresonator-based frequency combs; ultra-stable optical reference cavities; and cavity QED many-atom systems for clocks and sensing. The group is part of the EU iqClock project targeting operational optical lattice clocks.