Technique - (6) Diamond surface functionalization

Type: Fabrication

Description: Chemical/biological surface modification of diamond for biocompatible NV-sensor interfaces.

Department(s)/lab(s): PME | Esser-Kahn Lab @ UChicago
Summary:

Primary focus: immune engineering for vaccines and cancer immunotherapy. Quantum sensing relevance: co-authored 2025 fluorescent-protein spin qubit paper (Physics World Top-10) with Maurer and Awschalom, contributing protein engineering expertise to develop biological alternatives to NV centers. Collaborates on quantum biosensors for real-time monitoring of immune cell activity (Chan Zuckerberg Biohub). Primarily a collaboration gateway for NV biosensing rather than standalone quantum sensing PI.

Department(s)/lab(s): Chemistry | Hamers Group @ UWMadison
Summary:

Studies surface and interface chemistry of diamond and other materials, including the chemical functionalization and stabilization of near-surface NV and silicon-vacancy color centers used in diamond-based quantum sensors, in collaboration with the Choy group.

Department(s)/lab(s): Chemistry | Krueger Group (Institute of Organic Chemistry) @ Stuttgart
Summary:

Krueger's chemistry group develops diamond and nanodiamond surface chemistry, functionalization and bioconjugation that make NV centres viable, shallow, coherent quantum sensors for chemical and biological targets - the materials-chemistry enabler for NV ensemble sensing. She co-leads Stuttgart's quantum-technologies profile. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is enabled at the surface-chemistry level by this work.

Department(s)/lab(s): PME | Maurer Lab @ UChicago
Summary:

Develops quantum sensing platforms at the biology interface. Core NV-center work: (1) widefield NV magnetic imaging of action potentials in neurons and cardiac tissue; (2) NV-based single-molecule NMR at 14 T resolving molecular structure with single-molecule sensitivity; (3) charge-sensitive shallow NV nanoprobes monitoring real-time cellular electrophysiology; (4) biocompatible diamond surface functionalization enabling multiplexed DNA microarray biosensing; (5) fluorescent-protein spin qubits as biological alternatives to diamond NV (2025 paper, Physics World Top-10 Breakthrough). Runs full NV stack: hot implantation, widefield and confocal ODMR, T1/T2/Hahn echo/DEER/Rabi, automated fitting pipelines. 2026 Sloan Fellow. PhD Lukin/Harvard; postdoc Chu/Stanford. Argonne joint appointment.

Department(s)/lab(s): School of Physics | Melbourne Materials Institute Diamond Group (Prawer) @ UMelb
Summary:

Prawer is the founding figure of Melbourne diamond science, spanning colour-centre quantum technology, diamond surface chemistry and — unusually — clinical translation. His group developed the nitrogen-doped ultrananocrystalline diamond electrode arrays used in the Australian diamond bionic eye, a hermetically sealed, chronically implantable retinal stimulator that has been through human implantation; that is a rare example of an exotic-materials sensing/stimulation technology carried into human trials. In parallel the group works on diamond surface termination and functionalisation for near-surface NV sensing, nanodiamond bioconjugation, and diamond as a radiation-hard detector material. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — his surface- and materials-engineering work is precisely what sets the standoff distance, and hence the achievable pT/sqrt(Hz) sensitivity, of near-surface NV ensembles used for DEER and nanoscale NMR. Preferred attribute present: demonstrated human trials with a complex implanted technology.

Department(s)/lab(s): School of Physics | Quantum Imaging and Sensing Laboratory (Simpson) @ UMelb
Summary:

Simpson runs the experimental quantum imaging and sensing laboratory at Melbourne and is the closest match at this institution to a bio-oriented NV sensing postdoc. Two active threads: (i) widefield NV magnetic and spin-relaxation imaging of living cells and tissue, including magnetic imaging of magnetotactic bacteria, cellular free radicals and paramagnetic ion transport, and quantum-probe imaging of neuronal activity; and (ii) engineering Australia's most sensitive diamond vector magnetometer with RMIT and Phasor Innovation, aimed at navigation, underground/undersea sensing and, explicitly, mapping magnetic signals of the human brain in unshielded environments. That second thread is a direct bid at bioelectromagnetism with a quantum sensor. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — Simpson's work is a continuation of exactly that lineage, pushing ensemble DEER/T1-relaxometry contrast mechanisms out of the physics lab and into cell biology and human-scale magnetoencephalography. Preferred attributes present: bioelectromagnetism, human-subject ambitions, sensitivity-limited (not fabrication-limited) programme. QUBIC investigator; recruits postdocs regularly.