Knowles leads the Coherent Quantum Lab at the Cavendish Laboratory. Her research focuses on using NV centers in diamond as quantum sensors to probe matter at the nanoscale in two main thrusts: (1) nanoscale NMR / spin imaging — scanning-probe NV magnetometry of topological and unconventional magnets, Hamiltonian engineering in dense spin ensembles using global dynamical decoupling, and error-correction-enhanced sensor readout; (2) quantum biosensing in living systems — employing diamond nanocrystals functionalized for intracellular delivery to perform simultaneous nanothermometry and nanorheometry in single HeLa cells and C. elegans, using the Q-BiC integrated biocompatible chip platform. She co-leads CANSIS. The lab has a second new instrument running since mid-2025 for biosensing experiments.
Krueger's chemistry group develops diamond and nanodiamond surface chemistry, functionalization and bioconjugation that make NV centres viable, shallow, coherent quantum sensors for chemical and biological targets - the materials-chemistry enabler for NV ensemble sensing. She co-leads Stuttgart's quantum-technologies profile. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is enabled at the surface-chemistry level by this work.
Develops quantum sensing platforms at the biology interface. Core NV-center work: (1) widefield NV magnetic imaging of action potentials in neurons and cardiac tissue; (2) NV-based single-molecule NMR at 14 T resolving molecular structure with single-molecule sensitivity; (3) charge-sensitive shallow NV nanoprobes monitoring real-time cellular electrophysiology; (4) biocompatible diamond surface functionalization enabling multiplexed DNA microarray biosensing; (5) fluorescent-protein spin qubits as biological alternatives to diamond NV (2025 paper, Physics World Top-10 Breakthrough). Runs full NV stack: hot implantation, widefield and confocal ODMR, T1/T2/Hahn echo/DEER/Rabi, automated fitting pipelines. 2026 Sloan Fellow. PhD Lukin/Harvard; postdoc Chu/Stanford. Argonne joint appointment.
Treussart uses fluorescent nanodiamonds (NV centres) as photostable bio-probes: intracellular single-particle tracking, nanoscale thermometry/magnetometry, and multimodal biosensing in cells and organisms, alongside super-resolution imaging - a direct NV-ensemble-to-biology bridge. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is applied here to living cells via nanodiamond probes.