Research Areas - (6) NV Single-Molecule NMR

Full path: Physics > Quantum Sensing > NV Centers > NV Magnetometry > NV Single-Molecule NMR

Department(s)/lab(s): Physics (Cavendish Laboratory – AMOP Group) | Quantum Optical Materials and Systems (QOMS) @ Cambridge
Summary:

AtatΓΌre leads the ~30-person QOMS group at the Cavendish. Three main thrusts: (1) Spin-based quantum networks β€” demonstrating distant entanglement generation and photonic cluster states using semiconductor quantum dots (InGaAs, GaAs) and diamond spin defects (NV, SiV, SnV), including a many-body nuclear-spin quantum register demonstrated in 2025 (Nature Physics); (2) Quantum-enhanced nanoscale sensing β€” scanning NV diamond magnetometry of emergent magnetism in novel 2D/layered materials and quantum transport in nanocircuits, plus nanodiamond-based in-cell sensing (nanoMRI, thermometry, diffusion in C. elegans); (3) Novel quantum materials β€” hexagonal boron nitride (hBN) optically-active spin defects at room temperature, and moirΓ© physics in TMD heterostructures. He is co-founder and CSO of Nu Quantum Ltd.

Department(s)/lab(s): Physics – Laboratory for Solid State Physics | Degen Group (Spin Physics and Imaging) @ ETH Zurich
Summary:

Degen leads the Spin Physics and Imaging group, one of the world's leading NV-center magnetometry labs. Research directions (as of 2025): (1) Scanning NV magnetometry of quantum materials β€” NV-tipped cantilevers image current flow (≲50 nm resolution) in graphene heterostructures and resolve domain walls in antiferromagnets/ferroelectrics; cryogenic scanning down to 350 mK in dilution refrigerator (published Appl. Phys. Lett. 2022). (2) Single-molecule NMR β€” shallow NV centers detect nuclear spins from surface-adsorbed molecules with sub-nanometer 3D resolution; 2022 Nano Lett. on amine-functionalized diamond surfaces; exploring chirality-induced spin selectivity at few-molecule level. (3) NV magnetometry protocols β€” reconstruction-free waveform sensing (1.1 ns time resolution, Nature 2025), gradiometric detection, spectrum demodulation for rapid scanning, multi-NV addressing. (4) Diamond nanoengineering β€” multicone pillar waveguides, surface engineering, scanning probe fabrication. ERC Proof-of-Concept 2025 for photonic IC single-photon NV excitation/detection for commercial quantum sensing.

Department(s)/lab(s): BioNanoscience / Kavli Institute of Nanoscience | Cees Dekker Lab β€” Single-Molecule Biophysics & Nanobiology @ TU Delft
Summary:

Cees Dekker (Distinguished University Professor, BioNanoscience/Kavli) pioneered solid-state nanopores and single-molecule biophysics. Research: (1) solid-state nanopores for protein sensing and sequencing β€” detecting individual protein molecules by current blockade; (2) DNA loop extrusion by condensin and cohesin at the single-molecule level; (3) chromatin structure and chromosome organisation with bacteria-on-chip; (4) synthetic cell construction from the bottom up; (5) diagnostic nanopores for neglected diseases. NanoFront 51M€ NWO program leader; 2019 Nature paper on real-time DNA loop extrusion imaging.

Department(s)/lab(s): Physics (Cavendish Laboratory – AMOP Group) | Coherent Quantum Lab (Knowles Group) @ Cambridge
Summary:

Knowles leads the Coherent Quantum Lab at the Cavendish Laboratory. Her research focuses on using NV centers in diamond as quantum sensors to probe matter at the nanoscale in two main thrusts: (1) nanoscale NMR / spin imaging β€” scanning-probe NV magnetometry of topological and unconventional magnets, Hamiltonian engineering in dense spin ensembles using global dynamical decoupling, and error-correction-enhanced sensor readout; (2) quantum biosensing in living systems β€” employing diamond nanocrystals functionalized for intracellular delivery to perform simultaneous nanothermometry and nanorheometry in single HeLa cells and C. elegans, using the Q-BiC integrated biocompatible chip platform. She co-leads CANSIS. The lab has a second new instrument running since mid-2025 for biosensing experiments.

Department(s)/lab(s): PME | Maurer Lab @ UChicago
Summary:

Develops quantum sensing platforms at the biology interface. Core NV-center work: (1) widefield NV magnetic imaging of action potentials in neurons and cardiac tissue; (2) NV-based single-molecule NMR at 14 T resolving molecular structure with single-molecule sensitivity; (3) charge-sensitive shallow NV nanoprobes monitoring real-time cellular electrophysiology; (4) biocompatible diamond surface functionalization enabling multiplexed DNA microarray biosensing; (5) fluorescent-protein spin qubits as biological alternatives to diamond NV (2025 paper, Physics World Top-10 Breakthrough). Runs full NV stack: hot implantation, widefield and confocal ODMR, T1/T2/Hahn echo/DEER/Rabi, automated fitting pipelines. 2026 Sloan Fellow. PhD Lukin/Harvard; postdoc Chu/Stanford. Argonne joint appointment.

Department(s)/lab(s): Physics | 3rd Institute of Physics (Wrachtrup Group) @ Stuttgart
Summary:

Wrachtrup is a founder of NV-centre quantum sensing: single-spin and ensemble magnetometry, nanoscale/single-molecule NMR and ESR, nuclear-spin registers, scanning-probe quantum-materials imaging, and programmable diamond nanosensors for chemistry and biology. His group actively recruits postdocs across NV sensing and quantum technology. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is the reference point, extending DEER/nano-NMR toward single-molecule and cryogenic regimes.