Research Areas - (2) NV In-Cell Nanodiamond Multimodal Biosensing

Full path: Physics > Quantum Sensing > NV Centers > NV Thermometry > NV Nanodiamond In-Cell Thermometry and Rheometry > NV In-Cell Nanodiamond Multimodal Biosensing

Helena Knowles 🔗
University of Cambridge 🔗
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Department(s)/lab(s): Physics (Cavendish Laboratory – AMOP Group) | Coherent Quantum Lab (Knowles Group) @ Cambridge
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Knowles leads the Coherent Quantum Lab at the Cavendish Laboratory. Her research focuses on using NV centers in diamond as quantum sensors to probe matter at the nanoscale in two main thrusts: (1) nanoscale NMR / spin imaging — scanning-probe NV magnetometry of topological and unconventional magnets, Hamiltonian engineering in dense spin ensembles using global dynamical decoupling, and error-correction-enhanced sensor readout; (2) quantum biosensing in living systems — employing diamond nanocrystals functionalized for intracellular delivery to perform simultaneous nanothermometry and nanorheometry in single HeLa cells and C. elegans, using the Q-BiC integrated biocompatible chip platform. She co-leads CANSIS. The lab has a second new instrument running since mid-2025 for biosensing experiments.

Francois Treussart 🔗
Ecole Normale Superieure Paris-Saclay 🔗
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Department(s)/lab(s): Physics | LuMIn - NV & Nanodiamond Biosensing (Treussart) @ ENSPS
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Treussart uses fluorescent nanodiamonds (NV centres) as photostable bio-probes: intracellular single-particle tracking, nanoscale thermometry/magnetometry, and multimodal biosensing in cells and organisms, alongside super-resolution imaging - a direct NV-ensemble-to-biology bridge. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work is applied here to living cells via nanodiamond probes.