Daan Brinks develops all-optical electrophysiology tools for neuroscience. His lab engineers genetically-encoded voltage indicators (GEVIs) and combines them with optogenetics to read out and control neural circuit activity. Key directions: (1) engineering bright, fast GEVIs with improved photostability and voltage sensitivity; (2) multiplexed all-optical neural circuit mapping; (3) identifying rare aggressive cancer cells using voltage-sensitive dyes. His voltage imaging approach represents cutting-edge biosensing at the intersection of photonics and neuroscience.

Cohen's lab develops genetically encoded fluorescent voltage indicators and all-optical electrophysiology ('Optopatch') to simultaneously stimulate and image membrane voltage in individual neurons and cardiomyocytes at the single-cell and network level, combining protein engineering, optics, and theory to push the temporal and spatial resolution of bioelectrical imaging well past conventional patch-clamp limits.

David Maresca's lab pushes the boundaries of biomedical ultrasound imaging. Research: (1) functional ultrasound imaging of the brain at cellular resolution (vascular signal decoding, brain-computer interface applications); (2) engineering gas vesicle and microbubble acoustic contrast agents as genetically-encoded biosensors; (3) ultrafast ultrasound for cardiac imaging. The lab aims to image individual cells deep inside living organs using next-generation ultrasound. NWO Vici Grant (2026); Chan Zuckerberg Initiative Dynamic Imaging grant.

Miller designs synthetic VoltageFluor-class fluorescent dyes that report membrane potential with millisecond time resolution in neurons and other excitable cells, providing an optical alternative to patch-clamp electrophysiology for large-scale voltage imaging.