Description: High-frame-rate ultrasound imaging of cerebral blood volume changes for whole-brain functional mapping.
David Maresca's lab pushes the boundaries of biomedical ultrasound imaging. Research: (1) functional ultrasound imaging of the brain at cellular resolution (vascular signal decoding, brain-computer interface applications); (2) engineering gas vesicle and microbubble acoustic contrast agents as genetically-encoded biosensors; (3) ultrafast ultrasound for cardiac imaging. The lab aims to image individual cells deep inside living organs using next-generation ultrasound. NWO Vici Grant (2026); Chan Zuckerberg Initiative Dynamic Imaging grant.
Renaud develops nonlinear and single-sided ultrasound methods to characterize bone and vascular tissue in vivo — quantifying cortical bone porosity, blood-flow, and microbubble/microcrack acoustic signatures — and collaborates closely with David Maresca's functional-ultrasound group on transcranial aberration-corrected Doppler imaging of the brain. This acoustic biosensing work extends the lab's push toward higher-sensitivity, non-invasive acoustic biomarkers analogous in spirit to other quantum-adjacent biosensing modalities.
Tang develops super-resolution ultrasound imaging (localisation of microbubble contrast agents to resolve microvasculature below the diffraction limit) alongside contrast/functional ultrasound methods, applied to cancer, cardiovascular and neurological imaging.