Reilly's Quantum Nanoscience Laboratory works on the interface between quantum devices and the classical control hardware needed to run them at scale — custom VLSI CMOS operating below 100 mK, high-bandwidth dispersive readout, and cryogenic microwave engineering — a programme built up during his long association with Microsoft's quantum effort. A distinct and directly relevant second thread is the manipulation of spin states in nanoparticles for new imaging modalities in medicine: hyperpolarisation and spin-state engineering of nanoparticle contrast agents, which is quantum control applied to MRI. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the cryo-CMOS readout chain he builds is exactly the enabling technology that would let a pT/sqrt(Hz) spin-ensemble sensor be multiplexed into an array rather than run one channel at a time; and the nanoparticle-MRI thread is an independent route into biological spin sensing. Large group, strong engineering culture, significant industry entanglement.
Renaud develops nonlinear and single-sided ultrasound methods to characterize bone and vascular tissue in vivo — quantifying cortical bone porosity, blood-flow, and microbubble/microcrack acoustic signatures — and collaborates closely with David Maresca's functional-ultrasound group on transcranial aberration-corrected Doppler imaging of the brain. This acoustic biosensing work extends the lab's push toward higher-sensitivity, non-invasive acoustic biomarkers analogous in spirit to other quantum-adjacent biosensing modalities.
Bernd Rieger works on computational super-resolution microscopy and live tissue imaging at the nanoscale. Research directions: (1) single-molecule localization microscopy (SMLM) algorithms and particle fusion; (2) 3D multi-label super-resolution imaging in tissue; (3) deep learning for biological image analysis. ERC grants; NL-BI Dutch Bioimaging consortium.
Rowlands develops new optical imaging technologies for biology and medicine, including label-free vibrational (coherent Raman) microscopy and computational imaging approaches aimed at faster, higher-resolution biomedical imaging.
Giulia Rubino's research bridges quantum foundations and quantum technologies using integrated photonics. Research: (1) indefinite causal order — experimental demonstration of quantum switch using photonic chips; (2) quantum thermodynamics — fundamental limits of thermodynamic work extraction in quantum systems; (3) quantum information processing with photonic integrated circuits. Appointed Lecturer January 2024.
Rueda leads a single-molecule imaging group (jointly at Imperial and the MRC London Institute of Medical Sciences) that combines single-molecule FRET, fluorogenic RNA aptamer imaging and optical tweezers to reveal the structural dynamics of RNA folding/splicing, CRISPR-Cas9 target search and off-target activity, and chromatin-remodelling complexes; the aptamer-imaging technology has been spun out as the startup Irida.
Applies advanced single-molecule biosensing to study the cyanobacterial circadian clock — the only fully reconstitutable in vitro biochemical oscillator. Directions: (1) single-molecule FRET and fluorescence imaging to track conformational states of KaiC ATPase during clock cycles with single-protein resolution; (2) single-molecule reconstitution of the complete KaiA/KaiB/KaiC oscillator; (3) mathematical modeling of biochemical oscillation. Technique focus: single-molecule fluorescence as quantitative biosensing tool for protein conformational dynamics. Joint appointment Microbiology.
Sapienza studies light propagation and control in complex/disordered nanophotonic media, using wavefront shaping and transmission-matrix approaches to focus and image through scattering media, with applications to deep-tissue fluorescence imaging and nanophotonic light sources.
Marie-Claire Schanne-Klein (DR1 CNRS, LOB) specializes in polarized SHG and THG microscopy for structural tissue imaging. Research: (1) polarimetric SHG imaging of collagen fibril organization — molecular orientation mapping; (2) THG microscopy for myelin and red blood cell imaging; (3) structural and functional label-free imaging of connective tissues; (4) multi-scale SHG/THG analysis of biopolymer structure. SHG expert in LOB.
Uses single-molecule spectroscopy, optical trapping, and advanced imaging to study nanoscale systems. Directions: (1) orientation-resolved single-molecule spectroscopy using polarization-controlled excitation and detection; (2) optical trapping of individual nanoparticles and viruses to study force-dependent dynamics; (3) plasmon-enhanced single-molecule detection and imaging beyond diffraction limit; (4) ultrafast spectroscopy of nanoscale energy transfer.