Technique - (4) Wavefront shaping through scattering media (transmission matrix)

Type: Experimental

Description: Measuring and inverting the optical transmission matrix of biological scattering media to focus light deep in tissue; fluorescence imaging and quantum multimode optics through complex media.

Department(s)/lab(s): Physics – Laboratoire Kastler Brossel, Sorbonne UniversitΓ© | Optical Imaging in Complex Media Group (Gigan Group / LKB) @ Sorbonne
Summary:

Gigan leads the Optical Imaging group at LKB, pioneering wavefront shaping and computational imaging through scattering media. Research directions: (1) Wavefront shaping / transmission matrix β€” measuring the ~10^5 optical modes of a scattering sample's transmission matrix to focus and image through highly scattering biological tissues; roadmap on deep tissue imaging (J. Phys. Photonics 2022, lead author); (2) Multimode quantum optics through complex media β€” spatially multimode squeezed states transmitted through scattering media for quantum-enhanced imaging; (3) Optical computing / AI β€” using multiple scattering as a physical neural network for reservoir computing and nonlinear machine learning (LightOn spin-off, 2016); (4) Neurophotonics applications β€” focusing through the skull for deep brain imaging. Two ERC grants (2011, 2017). Optica Fellow. IUF member (2016–2021).

Department(s)/lab(s): Physics / LKB | PICO Group (Gigan Lab) @ ENS Paris
Summary:

Sylvain Gigan's PICO (Photonics, Information, and Complexity) group focuses on imaging through and with complex and scattering media. Research: (1) wavefront shaping through scattering media β€” adaptive optics and transmission matrix approaches for deep-tissue fluorescence imaging; (2) multimode quantum optics through complex media β€” pushing quantum light through scattering and multi-mode fibres; (3) analogue computing with random optical scattering media. Key for biosensing: deep tissue imaging at high spatial resolution and quantum-enhanced light manipulation.

Department(s)/lab(s): School of Physics | Roberts Optics and Meta-Optics Group @ UMelb
Summary:

Roberts leads Melbourne's optics group and is a chief investigator in the ARC Centre of Excellence for Transformative Meta-Optical Systems (TMOS). The work is about extracting information that conventional intensity imaging discards: metasurface-encoded point spread functions that recover the full polarisation state or quantitative phase in a single shot, subwavelength structures for edge enhancement and optical computing, and vectorial beam shaping. For a quantum-sensing candidate the relevant hook is that meta-optics is becoming the standard way to miniaturise the optical front end of NV, atomic-vapour and single-molecule sensors, and to add orientational sensitivity to imaging. Positioned against the established body of NV-ensemble quantum sensing work β€” DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β€” her metasurface collection optics and polarisation-resolved detection schemes are being applied to improve photon collection efficiency and orientational discrimination in exactly the NV-ensemble geometries used for pT/sqrt(Hz) magnetometry. Preferred attribute present: orientation-resolved methods that push past standard resolution limits.

Department(s)/lab(s): Physics | Photonics and Complex Media Group (Sapienza) @ Imperial
Summary:

Sapienza studies light propagation and control in complex/disordered nanophotonic media, using wavefront shaping and transmission-matrix approaches to focus and image through scattering media, with applications to deep-tissue fluorescence imaging and nanophotonic light sources.