Pioneer in nanocrystal science. Sensing-relevant directions: (1) coherent Er spin defects in colloidal nanocrystal hosts as scalable solid-state spin qubit platform (2024 paper with Awschalom); (2) size- and shape-controlled nanocrystal synthesis for mid-IR sensing applications; (3) fundamental scaling laws governing optical properties for sensor design. Founder Nanosys and Quantum Dot Corp.
Dai's lab pioneered second-near-infrared-window (NIR-II/SWIR) fluorescent nanomaterial probes -- including carbon nanotube and rare-earth-based emitters -- that dramatically reduce tissue scattering and autofluorescence, enabling deep-tissue in vivo optical imaging at spatial resolution unattainable with visible-light fluorophores.
Develops computational methods (DFT + many-body perturbation theory, quantum embedding) to predict properties of spin defects for quantum sensing and computing. Directions: (1) first-principles prediction of coherence properties, zero-phonon lines, and spin-photon coupling for NV, SiC divacancy, Er, and other color center platforms; (2) high-throughput screening of novel spin defect candidates in 2D materials and oxides; (3) quantum embedding methods for strongly correlated defects. Director MICCoM; NAS member; Argonne senior scientist.
Goldys was Deputy Director of the ARC Centre of Excellence for Nanoscale BioPhotonics and now leads a nanoscale biophotonics group in Biomedical Engineering. The programme is about extracting diagnostic information from very weak optical signals inside cells and tissue: luminescent and upconverting nanoparticle probes with long lifetimes that allow time-gated, background-free detection; hyperspectral unmixing of native cellular autofluorescence (NADH, FAD, porphyrins) as a completely label-free readout of cell state, which she has pushed toward clinical use in reproductive medicine and cancer; and nanoparticle-mediated therapy. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — time-gated luminescence and NV relaxometry are two solutions to the same problem — how to read a faint, specific signal out of an autofluorescent, optically hostile biological background — and her clinical translation experience is exactly the missing capability in most quantum-biosensing groups. Preferred attribute present: advanced/label-based imaging with a genuine human-application pathway.
Gooding is one of the world's most-cited biosensor scientists (inaugural editor-in-chief of ACS Sensors) and runs a group of over thirty researchers spanning surface chemistry, electrochemistry and nanomedicine. The sensing programme that matters here is the move from ensemble to digital, single-molecule-resolved detection: nanoparticle-tethered electrochemical sensors in which single binding events are counted rather than averaged, nanopore blockade sensors for protein biomarkers such as PSA, amplification-free nucleic-acid detection, and antifouling surface chemistries that make any of this work in real biological fluid. He has a strong commercialisation record (AgaMatrix glucose sensors). Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — his single-molecule-counting philosophy is the biosensing analogue of moving from a pT/sqrt(Hz) NV ensemble to single-spin detection: in both cases the sensitivity gain comes from resolving individual events rather than improving an averaged signal. He is also the obvious collaborator for anyone trying to functionalise a diamond or nanoparticle quantum sensor for a real analyte.
Graham's group develops SERS-based nanoplasmonic sensing platforms for biomedical applications. Research directions: (1) SERS nanogap substrates — engineering colloidal gold and silver nanostructure clusters with reproducible, high-enhancement nanogaps for single-molecule SERS detection; (2) In vivo SERS — intravenous SERS nanotags for tumor imaging and multiplexed biomarker detection in living organisms; (3) Microfluidic SERS — integrating SERS probes in microfluidic channels for continuous monitoring of circulating biomarkers; (4) Quantitative SERS — calibration strategies for absolute analyte quantification for clinical diagnostics. Extreme sensitivity (single-molecule) relevant to quantum-enhanced optical sensing.
Develops colloidal semiconductor nanocrystal platforms for infrared detection and sensing. Directions: (1) HgTe and HgSe colloidal quantum dot mid-IR photodetectors operating at room temperature — record sensitivity for solution-processed IR sensors; (2) electro-optic modulation using nanocrystal films at ultrafast timescales; (3) fundamental optical and transport properties of doped nanocrystals. Primary application: low-cost infrared imaging and chemical sensing.
Prof. Jacobsen's group develops novel methods, instruments, and analysis approaches for X-ray nanoscale imaging and applies them to biology and environmental science, using the Advanced Photon Source (APS) at Argonne. Directions: (1) Scanning X-ray fluorescence microscopy (SXFM) for organ-wide and nanoscale elemental mapping of metals (zinc, copper, iron) in biological tissues — central to the NIH-funded QE-Map national resource; imaging how metals regulate cellular functions, synaptic zinc signaling, and neurodegenerative disease; (2) X-ray ptychography and coherent diffractive imaging (CDI) for nanoscale biological imaging beyond the diffraction limit with improved dose efficiency; (3) Development of new algorithms, optics (zone plates), and detector systems to push spatial resolution and dose efficiency in X-ray microscopy — including lensless imaging methods and compressed-sensing reconstruction. Joint appointment at Argonne National Laboratory (Argonne Distinguished Fellow); also involved in QE-Map resource with Kozorovitskiy and Hao Zhang (McCormick).
Micolich works on semiconductor nanowire and organic/polymer nanoelectronic devices, with two strands relevant here: the physics of low-dimensional transport and noise in nanowire transistors, and the use of those devices as transducers at the interface with biological systems, where a nanowire field-effect transistor acts as an extremely local potentiometer sensitive to charge and potential changes at the cell membrane. The group has a strong record in noise spectroscopy — using 1/f and random telegraph noise as a diagnostic rather than a nuisance. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — nanowire FET bioelectronic sensing is the principal electrical competitor to NV-based bio-magnetometry: both aim to read out cellular electrophysiology without patch-clamping, one via magnetic fields at pT/sqrt(Hz), the other via local potential. Borderline inclusion, kept because the bio-interface sensing thread is genuine.
Prof. Mohseni's group (Bio-inspired Sensors and Optoelectronics) pushes III-V semiconductor photodetector technology toward thermodynamic and quantum limits of photon sensitivity. Key directions: (1) Nanoscale IR photodetectors: shrinking pixel dimensions below the diffraction limit using quantum confinement effects (InGaAs/InAlAs quantum well and dot structures) to improve sensitivity, bandwidth, and resolution simultaneously; (2) Superlattice photomultipliers — high-gain, low-noise avalanche photodetectors at room temperature approaching quantum-limited sensitivity for mid-wave and long-wave infrared detection; (3) Quantum sensing applications including squeezed-light-enhanced thermoreflectance imaging of electronic hotspots, and photon-counting receivers for quantum communications. Co-author on 275+ papers, 33+ US patents; NAI Fellow 2023; W.M. Keck Foundation Award, DARPA YFA, NSF CAREER. Fellow of SPIE and Optica. Also Professor of Physics and Astronomy.