Research Areas - (214) Biophysics

Full path: Biology > Biophysics

Department(s)/lab(s): Physics | Photonics Group (Biophotonics) @ Imperial
Summary:

Paterson develops adaptive-optics and wavefront-sensing techniques to correct optical aberrations in fluorescence microscopy and imaging through complex/turbid media, improving resolution and depth in biological and biomedical imaging.

Department(s)/lab(s): Physics | Quantum Imaging Group (Digistain) @ Imperial
Summary:

Phillips works on quantum imaging (entangled/twin-photon imaging at the quantum limit) and label-free mid-infrared spectroscopic biomedical imaging; he co-founded Digistain, a spin-out applying infrared spectroscopic histopathology to rapid cancer diagnostics.

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Department(s)/lab(s): Physics (LPENS) | Membrane Molecular Mechanisms Team (Pincet Lab) @ ENS Paris
Summary:

Pincet uses optical-tweezer single-molecule force spectroscopy and single-molecule imaging to quantify the energetics and kinetics of protein-membrane interactions underlying vesicle docking and fusion (synaptotagmin/SNARE machinery), and β€” as a 2020 ERC Synergy laureate β€” is testing whether the secretory pathway is organized as self-assembling 2D liquid-crystalline protein domains. The lab combines force-clamp optical tweezers with real-time single-molecule imaging for unprecedented spatiotemporal resolution of individual protein-membrane binding events.

Department(s)/lab(s): School of Physics | Melbourne Materials Institute Diamond Group (Prawer) @ UMelb
Summary:

Prawer is the founding figure of Melbourne diamond science, spanning colour-centre quantum technology, diamond surface chemistry and β€” unusually β€” clinical translation. His group developed the nitrogen-doped ultrananocrystalline diamond electrode arrays used in the Australian diamond bionic eye, a hermetically sealed, chronically implantable retinal stimulator that has been through human implantation; that is a rare example of an exotic-materials sensing/stimulation technology carried into human trials. In parallel the group works on diamond surface termination and functionalisation for near-surface NV sensing, nanodiamond bioconjugation, and diamond as a radiation-hard detector material. Positioned against the established body of NV-ensemble quantum sensing work β€” DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β€” his surface- and materials-engineering work is precisely what sets the standoff distance, and hence the achievable pT/sqrt(Hz) sensitivity, of near-surface NV ensembles used for DEER and nanoscale NMR. Preferred attribute present: demonstrated human trials with a complex implanted technology.

Department(s)/lab(s): Molecular and Cellular Biology, Applied Physics | Prigozhin Lab @ Harvard
Summary:

Prigozhin develops multicolor electron microscopy using cathodoluminescent nanoprobe protein tags and time-resolved cryo-vitrification methods to capture the nanoscale, sub-second dynamics of GPCR signaling and biomolecular condensate formation, aiming to add molecular-scale color and temporal resolution to electron microscopy's inherent nanoscale spatial resolution.

Department(s)/lab(s): School of Physics | Reece Optical Trapping and Nanophotonics Laboratory @ UNSW
Summary:

Reece runs UNSW's optical trapping and nanophotonics laboratory. The group combines optical tweezers with spectroscopy and microfluidics to characterise individual nanoparticles and cells: trapping and spectroscopically interrogating plasmonic core-satellite assemblies (with Gooding and Tilley), measuring single-cell mechanics, and building porous-silicon and photonic-crystal resonant structures for label-free biosensing where the analyte shifts a cavity resonance. Positioned against the established body of NV-ensemble quantum sensing work β€” DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β€” optical trapping is the standard way to hold a nanoscale sensor β€” including a nanodiamond hosting an NV ensemble at pT/sqrt(Hz) β€” at a controlled position inside a cell or fluid, and levitated-nanodiamond spin-mechanics is an active field that this group's capabilities map onto almost exactly. Strong practical fit for a bio-oriented quantum sensing candidate.

Department(s)/lab(s): LKB / Physics, Sorbonne UniversitΓ© | Atom Chips Group (Reichel/LKB) @ ENS Paris
Summary:

Jakob Reichel (Professor, LKB Atom Chips) leads work on fiber Fabry-Perot microcavities for atom-light quantum interfaces and miniaturised sensors. Research: (1) fiber Fabry-Perot microcavities β€” sub-micron mirrors on fibre tips enabling strong single-atom coupling; integrated directly into atom chips; (2) TACC (Trapped Atom Clock on a Chip) β€” Rb atom clock with 5.8Γ—10⁻¹³/βˆšΟ„ stability; ERC Advanced grant EQUEMI; (3) Sr optical-lattice cavity QED with quantum metrology; (4) MIREGA spinout β€” miniature portable greenhouse gas analyser combining FFP microcavities with telecom fibre optics for drone mounting; ERC Proof-of-Concept grant; (5) Rubidium CQED 'Sarocema' β€” individually addressable atom-tweezer array in fibre cavity for quantum simulation with long-range cavity-mediated interactions.

Department(s)/lab(s): School of Physics | Quantum Nanoscience Laboratory @ USyd
Summary:

Reilly's Quantum Nanoscience Laboratory works on the interface between quantum devices and the classical control hardware needed to run them at scale β€” custom VLSI CMOS operating below 100 mK, high-bandwidth dispersive readout, and cryogenic microwave engineering β€” a programme built up during his long association with Microsoft's quantum effort. A distinct and directly relevant second thread is the manipulation of spin states in nanoparticles for new imaging modalities in medicine: hyperpolarisation and spin-state engineering of nanoparticle contrast agents, which is quantum control applied to MRI. Positioned against the established body of NV-ensemble quantum sensing work β€” DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity β€” the cryo-CMOS readout chain he builds is exactly the enabling technology that would let a pT/sqrt(Hz) spin-ensemble sensor be multiplexed into an array rather than run one channel at a time; and the nanoparticle-MRI thread is an independent route into biological spin sensing. Large group, strong engineering culture, significant industry entanglement.

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Department(s)/lab(s): Imaging Physics | Renaud Group @ TU Delft
Summary:

Renaud develops nonlinear and single-sided ultrasound methods to characterize bone and vascular tissue in vivo β€” quantifying cortical bone porosity, blood-flow, and microbubble/microcrack acoustic signatures β€” and collaborates closely with David Maresca's functional-ultrasound group on transcranial aberration-corrected Doppler imaging of the brain. This acoustic biosensing work extends the lab's push toward higher-sensitivity, non-invasive acoustic biomarkers analogous in spirit to other quantum-adjacent biosensing modalities.

Department(s)/lab(s): Imaging Physics (ImPhys) | Rieger Lab @ TU Delft
Summary:

Bernd Rieger works on computational super-resolution microscopy and live tissue imaging at the nanoscale. Research directions: (1) single-molecule localization microscopy (SMLM) algorithms and particle fusion; (2) 3D multi-label super-resolution imaging in tissue; (3) deep learning for biological image analysis. ERC grants; NL-BI Dutch Bioimaging consortium.