Description: Uses electron-beam-induced cathodoluminescence from engineered inorganic nanoprobes ('cathodophores') acting as luminescent protein tags, adding molecular-scale color contrast to electron microscopy so ultrastructure and individual tagged proteins can be visualized in a single experiment.
Prigozhin develops multicolor electron microscopy using cathodoluminescent nanoprobe protein tags and time-resolved cryo-vitrification methods to capture the nanoscale, sub-second dynamics of GPCR signaling and biomolecular condensate formation, aiming to add molecular-scale color and temporal resolution to electron microscopy's inherent nanoscale spatial resolution.