Kelley designs nanostructured electrochemical biosensors -- including antifouling 'spiky' nanoelectrodes -- for amplification-free, point-of-care detection of nucleic acids and proteins (e.g. bacterial mRNA), aiming to replace slow, lab-based amplification assays with rapid electronic diagnostics deployable at the bedside.
Ladame develops biosensors and molecular diagnostic assays that detect cell-free circulating nucleic acid biomarkers (DNA/RNA) directly, without enzymatic amplification, for applications in early disease diagnosis and monitoring.
McKendry co-directs Q-BIOMED, the UK's national quantum-biomedical-sensing research hub (UKRI/NIHR, ~GBP24M), which brings NV-diamond and other quantum sensors into clinical diagnostics. Her own group has developed nitrogen-vacancy nanodiamond-labelled lateral-flow and rapid molecular tests -- including a quantum-enhanced SARS-CoV-2 antigen test and single-molecule HIV RNA detection -- that exploit resonant microwave control of the NV spin state to separate signal from background and push rapid point-of-care diagnostics toward single-molecule sensitivity, a direct human-diagnostics application of quantum sensing.
Micolich works on semiconductor nanowire and organic/polymer nanoelectronic devices, with two strands relevant here: the physics of low-dimensional transport and noise in nanowire transistors, and the use of those devices as transducers at the interface with biological systems, where a nanowire field-effect transistor acts as an extremely local potentiometer sensitive to charge and potential changes at the cell membrane. The group has a strong record in noise spectroscopy — using 1/f and random telegraph noise as a diagnostic rather than a nuisance. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — nanowire FET bioelectronic sensing is the principal electrical competitor to NV-based bio-magnetometry: both aim to read out cellular electrophysiology without patch-clamping, one via magnetic fields at pT/sqrt(Hz), the other via local potential. Borderline inclusion, kept because the bio-interface sensing thread is genuine.
Miller develops nitrogen-vacancy nanodiamond quantum biosensors for rapid diagnostics, controlling the NV spin state with resonant green/microwave illumination to frequency-separate fluorescence signal from background and achieve single-molecule detection of nucleic acids (e.g. HIV RNA with a short isothermal amplification step) in lateral-flow and widefield formats. His current projects span nanodiamond sensors for point-of-care disease diagnostics, quantum sensing at neural-interface implants, and wide-field quantum sensing of large randomly-oriented nanodiamond ensembles in biological samples, actively recruiting PhD students through the Q-BIOMED hub.
Mirkin invented spherical nucleic acids (SNAs) -- gold nanoparticles densely coated with a radial shell of oligonucleotides -- and their 'nanoflare' derivatives, which enter live cells without transfection agents and light up sequence-specifically upon binding intracellular mRNA, enabling live-cell gene-expression biosensing, circulating-tumor-cell isolation, and simultaneous mRNA detection/regulation. This label-based intracellular biosensing platform is offered as a borderline but well-established inclusion under the biosensing/dye-based imaging criterion.
Prawer is the founding figure of Melbourne diamond science, spanning colour-centre quantum technology, diamond surface chemistry and — unusually — clinical translation. His group developed the nitrogen-doped ultrananocrystalline diamond electrode arrays used in the Australian diamond bionic eye, a hermetically sealed, chronically implantable retinal stimulator that has been through human implantation; that is a rare example of an exotic-materials sensing/stimulation technology carried into human trials. In parallel the group works on diamond surface termination and functionalisation for near-surface NV sensing, nanodiamond bioconjugation, and diamond as a radiation-hard detector material. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — his surface- and materials-engineering work is precisely what sets the standoff distance, and hence the achievable pT/sqrt(Hz) sensitivity, of near-surface NV ensembles used for DEER and nanoscale NMR. Preferred attribute present: demonstrated human trials with a complex implanted technology.
Reece runs UNSW's optical trapping and nanophotonics laboratory. The group combines optical tweezers with spectroscopy and microfluidics to characterise individual nanoparticles and cells: trapping and spectroscopically interrogating plasmonic core-satellite assemblies (with Gooding and Tilley), measuring single-cell mechanics, and building porous-silicon and photonic-crystal resonant structures for label-free biosensing where the analyte shifts a cavity resonance. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — optical trapping is the standard way to hold a nanoscale sensor — including a nanodiamond hosting an NV ensemble at pT/sqrt(Hz) — at a controlled position inside a cell or fluid, and levitated-nanodiamond spin-mechanics is an active field that this group's capabilities map onto almost exactly. Strong practical fit for a bio-oriented quantum sensing candidate.
Sierecki co-developed the cell-free single-molecule interaction platform with Gambin and runs a group applying it to protein interaction networks: mapping which proteins bind which, with what affinity and in what stoichiometry, at throughput high enough to screen rather than characterise one pair at a time. Recent applications include viral protein-host interactions and transcription factor complexes. Positioned against the established body of NV-ensemble quantum sensing work — DEER, nanoscale NMR and T1 relaxometry protocols operating at pT/sqrt(Hz) field sensitivity — the relevance to a quantum-sensing candidate is as a source of well-characterised, quantitatively-defined biological targets: a pT/sqrt(Hz)-class sensor is only useful in biology if someone can tell you exactly what molecular species is present and at what concentration, which is what this platform delivers. Borderline inclusion — no quantum or physics-instrumentation component — kept because single-molecule technique development is the core of the group.
Soh's lab engineers aptamer- and SOMAmer-based electrochemical biosensors capable of real-time, continuous molecular measurement (drugs, metabolites, proteins) directly in living systems, aiming for closed-loop, quantitative point-of-care and in vivo diagnostics.