Summary: UCLQ coordinates ~120 researchers across a rich range of quantum sensing disciplines. The AMOPP group spans levitated optomechanics (Barker), atomic magnetometry and MIT imaging (Renzoni), femtosecond biosensing (Bain), quantum biology theory (Olaya-Castro), Rydberg atoms (Hogan), and molecular precision physics (Caldwell). The Biological Physics group (Llorente-Garcia) addresses quantum effects in biological systems. UCL is particularly notable for quantum sensing applied to biology, including radical-pair mechanisms, optical magnetometry for MEG, and super-resolution biosensing. The London Centre for Nanotechnology (LCN) provides shared fabrication facilities.
Notes: Top-10 UK research university (QS #9 global). The UCLQ Quantum Science and Technology Institute coordinates ~120 researchers. Key groups in scope: AMOPP group โ levitated optomechanics (Barker), atomic magnetometry / MIT imaging (Renzoni), femtosecond biosensing (Bain), quantum biology theory (Olaya-Castro), Rydberg atoms (Hogan), molecular precision physics (Caldwell), quantum optomechanics theory (Monteiro). Biological Physics group (Llorente-Garcia). Member of UK National Quantum Technologies Programme. London Centre for Nanotechnology shares facilities.
Bain develops advanced laser spectroscopy and super-resolution microscopy techniques for biological applications. Research directions: (1) Femtosecond time-resolved STED (stimulated emission depletion) โ combining sub-diffraction spatial resolution with picosecond time resolution to study FRET dynamics in live cells with both spatial and lifetime precision; (2) Time-resolved polarized fluorescence โ probing orientation distributions and rotational dynamics of fluorophores; (3) CW STED fluorescence lifetime reconstruction โ lower-photodose STED for longer live-cell imaging; (4) Single-molecule FRET to study protein-protein interactions; (5) Single-particle tracking of membrane receptors relevant to viral entry and cancer signaling. Former PhD students include Siรขn Culley (now King's College, SMLM).
Barker leads the UCL Optomechanics Group, focusing on levitated nano/micro-oscillators in vacuum. Research directions: (1) Six-degree-of-freedom cooling โ demonstrated simultaneous cavity cooling of all 6 DOF of a levitated nanoparticle (Nature Physics 2023, with Monteiro); (2) Sympathetic cooling of two nanoparticles via Coulomb interaction, squeezing transfer (Phys. Rev. Research 2023); (3) Dark matter searches โ levitated nanoparticles as directional dark matter sensors sensitive to nuclear recoil and momentum transfer; QTFP-funded project 'Development of Levitated Quantum Optomechanical Sensors for Dark Matter Detection'; (4) Controlling mode orientations for directional force sensing near the quantum limit; (5) Quantum macroscopic superposition tests. Closely collaborates with Monteiro (theory), Bose (quantum entanglement tests), and Ghag (dark matter).
Barnes co-developed (with Nottingham's Matt Brookes) OPM-MEG, the first wearable whole-head magnetoencephalography scanner: a helmet of optically-pumped magnetometer quantum sensors (spin-exchange-relaxation-free Rb vapour cells) that lets patients move naturally during a brain scan, inside an actively-nulled magnetically shielded room. His group has validated the system against cryogenic SQUID-MEG, deployed the UK's first paediatric OPM-MEG epilepsy clinic, and extended the technology to spinal-cord recording and naturalistic/VR paradigms -- a direct human-trials application of a quantum sensor whose femtotesla-scale sensitivity is comparable to the pT/sqrt(Hz)-class sensitivity sought from NV-ensemble magnetometry, but achieved with room-temperature atomic vapour cells rather than solid-state spin defects.
Bell's group uses DNA nanotechnology and advanced optical microscopy for single-molecule biosensing. Research directions: (1) DNA-based biosensing โ DNA origami structures as programmable biosensing platforms; using structural switching of DNA nanodevices to sense specific biomolecules with single-molecule sensitivity; (2) Super-resolution microscopy with DNA โ DNA-PAINT and FRET-based single-molecule localization for mapping molecular architectures in cells; (3) Solid-state nanopores โ DNA-threaded through nanopores as a precision biosensor for protein identification and force measurement; (4) Multiplexed single-molecule detection โ combining DNA-based sensors with optical readout for parallel biomolecule profiling. New group established at UCL, strong biosensing focus.
Bose originated (with Marletto and Vedral) the Bose-Marletto-Vedral (BMV) proposal to witness whether gravity is fundamentally quantum, by testing for gravitationally-induced entanglement between two spatially superposed masses using matter-wave (Stern-Gerlach) interferometry -- an idea he co-developed with quantum-sensing experimentalists including Andrew Geraci (Northwestern) and Peter Barker (UCL). He continues to develop the theory of these quantum-gravity-induced entanglement of masses (QGEM) tests, including decoherence mitigation and multi-qubit witnessing schemes, positioning nanocrystal/levitated-mass interferometry as a route to laboratory tests of quantum gravity.
Breeze is a senior research fellow at UCL working on room-temperature solid-state masers. Research directions: (1) Pentacene maser โ first demonstration of a room-temperature, continuous-wave solid-state maser (Science 2018) using photoexcited triplet-state pentacene in p-terphenyl crystal; achieving amplification with noise temperature near 1 K; (2) Diamond NV maser โ developing NV-center-based maser for ultra-low-noise microwave amplification at room temperature, relevant to quantum sensing readout chains; (3) Maser applications โ quantum-limited amplification for dark matter searches, MRI signal amplification, and quantum communication repeaters; (4) Spin dynamics โ understanding triplet-state dynamics in organic crystals for spin polarization control. Strong relevance to quantum-limited microwave sensing.
Caldwell is a Royal Society University Research Fellow establishing the Molecular Quantum Matter Lab at UCL. Research directions: (1) Precision molecular spectroscopy for dark matter and fifth-force searches โ measuring isotope shifts in molecular systems to test Standard Model predictions and probe new forces between neutrons and electrons; (2) Quantum control of molecules in external fields โ laser cooling, Stark deceleration, and magneto-optical trapping of polar molecules; (3) Molecular beam spectroscopy with frequency comb referencing for ultra-high-precision lineshape measurements. The lab aims to build the most precise molecular spectrometer for BSM physics searches. Actively building the lab and seeking motivated students/postdocs.
Cassidy's group performs precision optical and microwave spectroscopy of positronium -- a purely leptonic electron-positron atom -- to test bound-state QED to high order and search for new physics, most recently a precision microwave measurement of the 2^3S1 to 2^3P2 fine-structure interval. The group is also developing slow, focused positronium beams toward a laboratory measurement of antimatter's gravitational free-fall, continuing UCL's 50-year history of positron physics.
Hogan's group studies atoms and molecules in high Rydberg states for precision measurements and quantum sensing. Research directions: (1) Rydberg atom electric field sensing โ Rydberg atoms exhibit enormous electric polarizabilities; Stark-map and EIT-based electrometry with sub-mV/cm sensitivity and GHz-range frequency coverage; (2) Rydberg molecule spectroscopy โ long-range Rydberg molecules as probes of intermolecular forces; (3) Stark deceleration and trapping of Rydberg atoms/molecules โ producing cold samples for precision spectroscopy and scattering experiments; (4) Circular Rydberg states โ extremely long-lived states for quantum information storage and sensing. Collaborates on quantum-enhanced sensing of RF/microwave fields.
Hoogenboom leads a biophysics group at UCL specializing in high-speed atomic force microscopy. Research directions: (1) High-speed AFM โ imaging conformational dynamics of DNA, proteins (including membrane channels), and chromatin at ms time resolution and sub-nm spatial resolution in aqueous conditions; (2) Nuclear pore complex โ mapping transport selectivity and structure of NPCs in native nuclear envelopes using AFM; (3) Antimicrobial mechanisms โ imaging membrane disruption by antimicrobial peptides in real time; (4) AFM-based force spectroscopy โ measuring single-molecule interaction forces in chromatin and protein assemblies. Strong relevance to biological sensing at the single-molecule level.