Kaminski's Laser Analytics Group develops laser-based super-resolution and fluorescence-lifetime imaging methods (STED, SIM, dSTORM, FLIM) and applies them, with long-time collaborator Gabriele Kaminski Schierle, to visualise amyloid protein aggregation in live cells and organisms as a route to understanding neurodegenerative disease; the group also directs the EPSRC Centre for Doctoral Training in Sensor Technologies.

Kaminski Schierle heads the Molecular Neuroscience Group, applying super-resolution and functional fluorescence imaging (developed with Clemens Kaminski) to gain molecular-level understanding of protein misfolding in Alzheimer's, Parkinson's and Huntington's disease models, including live-cell and whole-organism (C. elegans) imaging of amyloid aggregation.

Keyser's group uses solid-state and DNA-origami nanopores for resistive-pulse single-molecule sensing, with a current focus on multiplexed RNA identification using barcoded DNA nanostructures, in close collaboration with Jeremy Baumberg's plasmonics group. The lab combines physics, nanofabrication and molecular biology to push nanopore sensing toward diagnostic applications.

Klenerman develops and applies single-molecule fluorescence and scanning-probe methods (including nanopipette scanning ion-conductance microscopy and a single-objective oblique-plane light-sheet microscope) to study protein misfolding and aggregation in neurodegenerative disease, alongside his earlier work co-inventing next-generation DNA sequencing.

Knowles leads the Coherent Quantum Lab at the Cavendish Laboratory. Her research focuses on using NV centers in diamond as quantum sensors to probe matter at the nanoscale in two main thrusts: (1) nanoscale NMR / spin imaging — scanning-probe NV magnetometry of topological and unconventional magnets, Hamiltonian engineering in dense spin ensembles using global dynamical decoupling, and error-correction-enhanced sensor readout; (2) quantum biosensing in living systems — employing diamond nanocrystals functionalized for intracellular delivery to perform simultaneous nanothermometry and nanorheometry in single HeLa cells and C. elegans, using the Q-BiC integrated biocompatible chip platform. She co-leads CANSIS. The lab has a second new instrument running since mid-2025 for biosensing experiments.

Lee leads TheLeeLab at Cambridge Chemistry, focused on developing cutting-edge biophysical single-molecule fluorescence methods to answer fundamental biological questions. Two major thrusts: (1) 3D super-resolution microscopy instrument development — the lab pioneered single-molecule light field microscopy (SMLFM) using a microlens array in the back focal plane, achieving ~10× speed improvement over double-helix PSF for volumetric imaging; also develops vortex light field microscopy (VLFM) for simultaneous 25 nm spatial / 3 nm spectral precision; (2) Biological applications — studying T-cell receptor signalling at the nanoscale (distribution of TCRs, microvilli-mediated close contacts), histone assembly during DNA replication and repair in fission yeast, and PSD-95 nanoclusters in mouse brain using 3D SMLM. A job posting (PDRA) was active in 2025 for T-cell imaging work with super-resolution and Fourier light-field microscopy.

Madhusudhan pioneered inverse 'atmospheric retrieval' techniques to determine the chemical composition, interior structure and formation history of exoplanets from their spectra, including recent JWST-based investigations of potential biosignature gases on temperate sub-Neptunes (Hycean worlds).

Maiolino investigates the formation, evolution and transformation of galaxies and black holes, with a current focus on the discovery and characterisation of massive black holes and Pop III star signatures in the early Universe using JWST/NIRSpec; he is also Project Scientist for the MOONS multi-object spectrograph (VLT) and the ANDES high-resolution spectrograph (ELT).

Markoff studies the extreme physics of accretion and jet formation around black holes of all scales, combining multi-wavelength observations with computational simulations; she is a founding member of the Event Horizon Telescope collaboration that produced the first black hole images, and co-leads a new EHT station in Namibia.

McMahon develops data-intensive, multi-wavelength observational techniques for wide-field imaging surveys (including gravitationally lensed quasar discovery in Gaia data) and plays a leading role in the Square Kilometre Array (SKA) and MOONS spectrograph projects, as well as national AI research infrastructure for astronomy.