Soh's lab engineers aptamer- and SOMAmer-based electrochemical biosensors capable of real-time, continuous molecular measurement (drugs, metabolites, proteins) directly in living systems, aiming for closed-loop, quantitative point-of-care and in vivo diagnostics.
Sokolov develops femtosecond adaptive spectroscopic techniques for coherent Raman (FAST CARS), broadband stochastic laser fields, and quantum-light probes of molecular coherence for standoff chemical/biological sensing and label-free imaging. In the broader landscape of NV-centre ensemble quantum sensing (DEER, nano-NMR, T1 relaxometry) operating near pT/sqrt(Hz) sensitivity, this work contributes ultrafast coherent-Raman methodology adjacent to spin-based sensing.
Research centers on manipulating and measuring single molecules with quantum-level precision. Primary platform: ABEL trap (Anti-Brownian ELectrokinetic trap) for single-molecule confinement in free solution without surface tethering, enabling measurement of spectroscopic identity, molecular dynamics, and nanoscale energy transfer at femtomolar concentrations. Also develops orientation-resolved single-molecule imaging and single-molecule FRET for photoadaptation in photosynthetic systems and nanoscale immune cell signaling. QuBBE member. PhD Physics UChicago; joined 2024.
Sjoerd Stallinga develops computational methods and hardware for super-resolution fluorescence microscopy. Research: (1) 3D single-molecule localization microscopy (3D SMLM) in living cells and tissue; (2) structured illumination microscopy (SIM) with noise-controlled reconstruction; (3) Fisher information framework for SMLM localization precision; (4) optical metrology for nanoscale structure characterization. ERC Advanced Grant for 3D super-resolution in living tissue.
Chiara Stringari (CRCN CNRS, LOB) develops FLIM-based metabolic imaging. Research: (1) fluorescence lifetime imaging microscopy (FLIM) of NAD(P)H and FAD in live tissue for label-free metabolic mapping; (2) phasor analysis of FLIM data for cellular metabolism states; (3) imaging of myelin dynamics using label-free nonlinear microscopy; (4) metabolic imaging in development and disease. 2025 paper on myelin in Optica.
Willy Supatto (DR2 CNRS, LOB) develops ultrafast two-photon light-sheet microscopy for quantitative in vivo imaging of embryo development and tissue dynamics. Research: (1) two-photon SPIM (light-sheet) for volumetric live imaging in zebrafish embryos; (2) SHG imaging of fibrillar proteins; (3) polarization-THG microscopy of structural anisotropy; (4) photodamage in multiphoton imaging. Part of key LOB team with Beaurepaire.
Tang develops super-resolution ultrasound imaging (localisation of microbubble contrast agents to resolve microvasculature below the diffraction limit) alongside contrast/functional ultrasound methods, applied to cancer, cardiovascular and neurological imaging.
Tank is a pioneer of two-photon laser-scanning microscopy for imaging calcium dynamics in dendrites and neural circuits in vivo, and co-directs the Bezos Center for Neural Circuit Dynamics, which develops large-scale optical recording instrumentation combined with rodent virtual-reality systems to study persistent neural activity and short-term memory. His group's methodological contributions to cellular-resolution optical imaging underpin much of modern systems neuroscience.
Tastevin is a long-standing member of LKB's polarized-helium team, developing optical-pumping hyperpolarization methods for 3He gas used both in fundamental quantum-fluid studies and in hyperpolarized-gas MRI for high-contrast, label-free imaging of lung airspaces.
Pioneers living bioelectronics integrating semiconductor nanostructures with biological systems. Primary directions: (1) silicon nanowire / nanoporous silicon photoelectrochemical interfaces for optical neuromodulation with subcellular spatial resolution; (2) intracellular silicon nanowire probes for recording action potentials from individual organelles; (3) bioinspired flexible mesh electronics for in vivo neural and cardiac interfaces. QuBBE member. 2026 Marian and Stuart Rice Research Award.