Description: Photo-activated (PALM) or stochastic optical reconstruction (STORM) super-resolution fluorescence imaging achieving ~10-20 nm lateral resolution in fixed and live cells.
Zhuang invented STORM super-resolution microscopy and MERFISH multiplexed spatial transcriptomics, and her lab continues to push single-molecule and multiplexed imaging techniques (e.g. a recent whole-olfactory-system map) to resolve cellular structures and RNA populations at nanometer-to-single-molecule resolution, well beyond the diffraction limit.