Description: Combinatorial, multiplexed single-molecule FISH imaging that reads out hundreds to thousands of RNA species in situ with single-molecule sensitivity and spatial resolution.
Zhuang invented STORM super-resolution microscopy and MERFISH multiplexed spatial transcriptomics, and her lab continues to push single-molecule and multiplexed imaging techniques (e.g. a recent whole-olfactory-system map) to resolve cellular structures and RNA populations at nanometer-to-single-molecule resolution, well beyond the diffraction limit.