Dickinson's group develops advanced optical microscopy methods for biological and biomedical imaging. Research directions: (1) STORM super-resolution microscopy — stochastic optical reconstruction for nanoscale imaging of biological structures at ~20 nm lateral resolution; imaging cytoskeletal dynamics, cellular organelles, and pathological structures; (2) Optical coherence tomography (OCT) — depth-resolved, label-free imaging for biomedical diagnostics (retinal, cardiovascular tissues); (3) Laser speckle imaging — blood flow and perfusion measurements in tissues; (4) Multiphoton microscopy — second harmonic generation (SHG) and two-photon for collagen structure imaging in connective tissues and cancer. Part of the Manchester Photon Science Institute biophotonics theme.

Xu develops STORM and related single-molecule-localization super-resolution imaging methods, along with new fluorogenic and multiplexed labeling strategies, to visualize cellular ultrastructure at ~10-20 nm resolution. The group is actively recruiting postdocs.

Zhuang invented STORM super-resolution microscopy and MERFISH multiplexed spatial transcriptomics, and her lab continues to push single-molecule and multiplexed imaging techniques (e.g. a recent whole-olfactory-system map) to resolve cellular structures and RNA populations at nanometer-to-single-molecule resolution, well beyond the diffraction limit.