Technique - (1) 3D polarized light imaging (scattered light polarimetry)

Type: Experimental

Description: Polarimetric transmission/scattering measurement of birefringent tissue to reconstruct 3D fiber orientation with micrometer resolution.

Department(s)/lab(s): Imaging Physics | Menzel Lab @ TU Delft
Summary:

Menzel's group develops computational scattered-light imaging methods, principally 3D Polarized Light Imaging (3D-PLI) and coherent Fourier scatterometry, to reconstruct the crossing-fiber architecture of unstained brain tissue at micrometer resolution without labeling. The lab combines birefringence/diattenuation measurements with finite-difference time-domain light-scattering simulations to push orientation resolution of nerve-fiber tracts beyond what diffusion MRI or standard histology can achieve, and is actively recruiting postdocs to extend the technique to new tissue types and label-free contrast mechanisms.