Research Areas - (1) Magnetogenetic Cell Signaling Control

Full path: Biology > Biophysics > Quantum Biology / Biosensing > Magnetic Nanoparticle Biosensing and Theranostics > Magnetogenetic Cell Signaling Control

Department(s)/lab(s): Department of Physics, 2nd Institute of Physics | Monzel Group - Biophysics and Biophotonics (2. Physikalisches Institut) @ Stuttgart
Summary:

Monzel holds the biophysics/biophotonics professorship at Stuttgart's 2nd Institute of Physics. The group develops multiparametric imaging spectroscopy and high-resolution light microscopy -- combining super-resolution, fluorescence-fluctuation and lifetime-resolved methods -- to read out several observables at once in living cells and in biomimetic model membranes, and pairs this with magnetic nanoparticles used to apply and sense forces on cell-surface receptors (magnetogenetic control of signalling). Single-molecule analysis inside cells is an explicit focus. Relative to the established NV-ensemble quantum-sensing playbook (DEER, nanoscale NMR, T1 relaxometry at pT/sqrt(Hz) ensemble sensitivity), this is the closest thing at Stuttgart to a natural biological host for in-cell quantum sensing: the group already does single-molecule-resolution live-cell imaging and already works with magnetic nanoparticles, so nanodiamond relaxometry/thermometry would slot in with the readout stack it already runs. Relatively new appointment -- good moment to join.