Research Areas - (1) DNA-PAINT Super-Resolution Microscopy

Full path: Biology > Biophysics > Quantum Biology / Biosensing > Super-resolution Microscopy > DNA-PAINT Super-Resolution Microscopy

Department(s)/lab(s): School of Life Sciences (SV) | Schueder Lab (High-Resolution Microscopy) @ EPFL
Summary:

Schueder is a newly appointed (2025) EPFL Assistant Professor specializing in high-resolution microscopy and its biological applications. He played a key role in the development of DNA-PAINT, a super-resolution microscopy technique enabling nanometer-scale (~5 nm) visualization of cellular structures via transient programmable DNA hybridization. Research directions: (1) DNA-PAINT super-resolution — multiplexed, quantitative imaging of protein complexes in fixed and living cells with Exchange-PAINT; (2) Single-molecule localization below 5 nm resolution — resolving individual proteins within complexes; (3) Biological applications — imaging cytoskeletal networks, receptor clustering, chromatin organization; (4) Expanding to in situ structural biology — correlating super-resolution images with cryo-EM data. Transferred from ETH Zurich. Strong fit with EPFL imaging and structural biology ecosystem.