Description: Imaging modality in which a specimen's own molecules participate in a distributed, self-organizing DNA tagging/amplification reaction; sequencing of the resulting DNA network is computationally decoded into a spatial map of molecular identity, bypassing conventional optics.
Weinstein invented DNA microscopy, in which a specimen's own transcripts participate in a distributed, self-organizing DNA reaction network that is later decoded by sequencing into a spatial map of gene expression, entirely without lenses or optics; he has since extended this to volumetric, whole-organism 3D spatial transcriptomics in intact zebrafish embryos. Where NV-ensemble sensors push magnetic-field spatial resolution optically (DEER/NMR/T1 at pT/sqrt(Hz)), Weinstein's technique achieves spatial resolution of molecular identity through a chemical/sequencing route instead, representing a fundamentally different route to super-resolved spatial biology.