Research Areas - (1) Optics-Free DNA Microscopy

Full path: Biology > Biophysics > Biophotonic Imaging > Optics-Free DNA Microscopy

Department(s)/lab(s): Molecular Engineering and Genetic Medicine | Weinstein Lab @ UChicago
Summary:

Weinstein invented DNA microscopy, in which a specimen's own transcripts participate in a distributed, self-organizing DNA reaction network that is later decoded by sequencing into a spatial map of gene expression, entirely without lenses or optics; he has since extended this to volumetric, whole-organism 3D spatial transcriptomics in intact zebrafish embryos. Where NV-ensemble sensors push magnetic-field spatial resolution optically (DEER/NMR/T1 at pT/sqrt(Hz)), Weinstein's technique achieves spatial resolution of molecular identity through a chemical/sequencing route instead, representing a fundamentally different route to super-resolved spatial biology.