O'Hare develops electrochemical and optical biosensors for point-of-care and near-patient diagnostics, including miRNA cancer biomarker detection and exhaled-breath-condensate analysis for respiratory and metabolic disease monitoring.

Wysocki develops quantum-cascade-laser-based spectroscopic sensing systems, including external-cavity QCLs, dispersion spectroscopy, and mid-IR dual-comb spectrometers, that routinely reach fundamental quantum-noise detection limits for trace-gas sensing; applications span atmospheric/environmental monitoring, drone-based methane leak detection, industrial process control, and human breath-based metabolic/medical diagnostics.