Arjen Jakobi (Associate Professor, BioNanoscience) uses cryo-electron microscopy and tomography for structural cell biology. Research: (1) cryo-ET in-cell structural biology — resolving protein complexes at near-atomic resolution inside vitrified cells; (2) autophagy and membrane remodelling — structural mechanism of autophagosome biogenesis; (3) integrin signalling complexes. Develops algorithms for sub-tomogram averaging and de-novo model building.