Defienne leads the Quantum Imaging Paris group at INSP, using spatial correlations and Hong-Ou-Mandel-type interference between entangled photon pairs to build microscopes that see through scattering media and correct optical aberrations without a spatial light modulator. His ERC-funded CORAMI project develops correlation-based adaptive optics as a universal add-on module for existing microscopes, targeting deeper (>1 mm), higher-contrast in-vivo imaging for neuroscientists, dermatologists, and ophthalmologists.